Results 221 to 230 of about 21,985 (305)

Analytical fleet-sizing method for the Open Platform for Innovation in Logistics (OPIL). [PDF]

Sci Rep
Körösi L, Duchoň F.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

DiscoVir: an automated, web-based pipeline for viral metagenomics. [PDF]

Microbiol Resour Announc
Krausfeldt LE, Subramanian P, Doan D, McCauley K, Dolan M, Hurt DE.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Protocol for predicting single- and multiple-dose-dependent gene expression using deep generative learning. [PDF]

STAR Protoc
Bowman DE, Panda V, Marri D, Kana O, Bhattacharya S.   +4 more
europepmc   +1 more source

Understanding Application Containerization with Docker and Docker Swarm

International Journal of Science and Research (IJSR)
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

DrugForm-TAS: Target-Agnostic Selectivity as Proteome-wide Binding Propensity Estimation. [PDF]

Comput Struct Biotechnol J
Tashchilova A, Khokhlov I, Seikin A, Bugaev-Makarovskiy N, Glushkova O, Yudin V, Keskinov A, Yudin S, Svetlichnyy D, Skvortsova V.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Protocol for the enhanced analysis of electrophysiological data from high-density multi-electrode arrays with nicespike and spikeNburst. [PDF]

STAR Protoc
Wolff R, Polito A, Buccino AP, Chiappalone M, Tucci V.   +4 more
europepmc   +1 more source