Results 191 to 200 of about 293,887 (293)

Dual Targeting of Tau Kinases and Autophagy by Abemaciclib Independent of CDK4/6 Inhibition

Advanced Science, EarlyView.
Abemaciclib rescues cognitive function and attenuates tau pathology in Alzheimer's disease models, but not through its known cancer‐fighting mechanism. This study demonstrates that abemaciclib operates independently of CDK4/6 inhibition, instead directly targeting tau kinases CaMKII and GSK3β while simultaneously promoting autophagic clearance of ...
Jihui Han, June‐Hyun Jeong, Dongjoon Lee, Yujin Jung, Yujin Jin, Eun Sun Jung, Haeng Jun Kim, Woo Youn Kim, Chang‐Han Lee, Inhee Mook‐Jung   +9 more
wiley   +1 more source

Highly enantioselective reduction of benzophenones by engineered Geotrichum candidum alcohol dehydrogenase. [PDF]

Appl Microbiol Biotechnol
Tang Z, Otárola Tejada GG, Koesoema AA, Matsuda T.   +3 more
europepmc   +1 more source

Additional file 3 of Two cases of TBL1XR1 heterozygous variants in children: a new splicing site variant identification and functional analysis through molecular docking and molecular dynamics simulation

Yaxue Xie, Z. Y. Zhang, Gang Zhu, Zhichao Li, Huiling Zhang, Jiaqi Zhang, Lin Wan, Guang Yang   +7 more
openalex   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Investigating the Anti-Inflammatory Activity of Juglans regia Fresh Fruit Extract. [PDF]

Foods
Marinaccio L, Procino E, Gentile G, Pieretti S, Cichelli A, Mollica A, Stefanucci A.   +6 more
europepmc   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, EarlyView.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Lipopeptides from <i>Bacillus</i> Probiotics Can Target Transmembrane Receptors NOX4, EGFR, PDGFR, and OCTN2 Involved in Oxidative Stress and Oncogenesis. [PDF]

BioTech (Basel)
Prazdnova E, Amirdzhanov F, Ranjan A, Skripnichenko R.   +3 more
europepmc   +1 more source

Effect of Fat-Tail Docking on the Reproductive Performance in Ghezel and Mehraban Sheep [PDF]

, 2016
H. Atashi, J. Izadifard
openalex  

Special issue : spaceplane plan of Japan and related elemental technology for HOPE rendezvous and docking.

, 1991
Yasufumi Wakabayashi
openalex   +2 more sources

Docking [PDF]

, 2020
openaire   +1 more source