Results 191 to 200 of about 629,692 (340)

Other title: Legislative Message and Budget Report Other title: Message of Robert B. Docking to the Kansas Legislature

, 1971
application/pdf; "January 20, 1971."; Includes Budget Message and Highlights of the Budget Report for the Fiscal Year ...
Kansas. Governor (1967-1975 : Docking)
core  

Evaluating molecular docking for binding affinity predictions: a systematic analysis of key parameters and the utility of AlphaFold2 structures for the Schrödinger dataset. [PDF]

J Comput Aided Mol Des
Tornesakis K, Essex JW, Cox PA, König G.   +3 more
europepmc   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Exploring the Mechanism of Zhigancao Decoction in the Treatment of Chronic Heart Failure via Modulation of Oxidative Stress. [PDF]

Rapid Commun Mass Spectrom
Luo Z, Huang Y, Tian Y, Huang S, Li F.
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Other title: Legislative Message and Budget Report; Other title: Message of Robert B. Docking to the Kansas Legislature

, 1974
application/pdf; "January 9, 1974."; Includes Budget Message and Highlights of the Budget Report for the Fiscal Year ...
Kansas. Governor (1967-1975 : Docking)
core  

Novel Peptide-Triazole Conjugates: Strategic Synthesis, Antimicrobial Properties, and Molecular Docking Study. [PDF]

J Pept Sci
Bhavsar J, Tivari S, Pati SS, Bhanderi P, Makwana B, Khunt R, Kumar N, Chaturvedi VK, Singh R.   +8 more
europepmc   +1 more source

Supercomputer Docking

Supercomputing Frontiers and Innovations, 2019
Alexey V. Sulimov, Danil C. Kutov, Vladimir B. Sulimov   +2 more
openaire   +2 more sources

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Other title: Legislative Message and Budget Report Other title: Message of Robert B. Docking to the Kansas Legislature

, 1968
application/pdf; "January 11, 1968."; Includes Budget Message and Highlights of the Budget Report for the Fiscal Year ...
Kansas. Governor (1967-1975 : Docking)
core