Results 261 to 270 of about 697,276 (400)

Robust Controlled Degradation of Enzyme Loaded PCL‐Based Fibrous Scaffolds Toward Scarless Skin Tissue Regeneration

Advanced Science, EarlyView.
A novel biodegradable wound dressing (E‐PCLs) based on polycaprolactone (PCL) and an enzyme complex (RHP‐BCL) is developed using a fiber microfluidic electrospinning technique. The dressing achieves complete degradation within 14 days, eliminates microplastic residues, and promotes scar‐free healing (99% in 21 days).
Lingling Fan, Weiliang Dong, Jianqi Lu, Yujia Peng, Bin Xie, Ping Wei, Min Jiang, Su Chen   +7 more
wiley   +1 more source

Moldina: a fast and accurate search algorithm for simultaneous docking of multiple ligands. [PDF]

J Cheminform
Halfar R, Damborský J, Marques SM, Martinovič J.   +3 more
europepmc   +1 more source

Identification and Application of a Novel Patulin Degrading Enzyme From Meyerozyma guilliermondii

Advanced Science, EarlyView.
Patulin (PAT), a hazardous mycotoxin, threatens human health. A novel yeast‐derived short‐chain dehydrogenase/reductase effectively degrades PAT into nontoxic ascladiol via catalytic triad activity. The biological detoxification process has no significant effect on the quality of fresh pear juice.
Yu Zhang, Qianhua Zhao, Solairaj Dhanasekaran, Esa Abiso Godana, Yue Zhang, Xue Bai, Qiya Yang, Hongyin Zhang   +7 more
wiley   +1 more source

Integrating Machine Learning-Based Pose Sampling with Established Scoring Functions for Virtual Screening. [PDF]

J Chem Inf Model
Vu TNL, Fooladi H, Kirchmair J.
europepmc   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Report of the committee of inventions, of the Franklin Institute, on the plan of a floating dry dock, invented by Edward Clark, Civil Engineer [PDF]

Thomas Peter Jones
openalex   +1 more source

Essential oil-derived compounds target core fatigue-related genes: A network pharmacology and molecular Docking approach. [PDF]

PLoS One
Dakpa G, Chiang YT, Lin LY, Tsao NW, Wang CH, Pérez-Sánchez H, Fernández JRA, Wang SY.   +7 more
europepmc   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

How to reduce intraoperative preparation and docking time to minimal in a team with a robotic naïve surgical experience? [PDF]

Urol Ann
Kallidonis P, Tatanis V, Tsaturyan A, Peteinaris A, Faitatziadis S, Faria-Costa G, Gkeka K, Spinos T, Vrettos T, Al-Aown A, Stolzenbur JU, Liatsikos E.   +11 more
europepmc   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou, Meng Gao, Shikun Zhang, Wing‐Wa Guo, Wenzhi He, Minghe Zhang, Xi Chen, Cairang Dongzhi, Xiaomian Li, Yufeng Yuan, Weijie Ma   +10 more
wiley   +1 more source