Results 341 to 350 of about 697,276 (400)

Drug repurposing targeting COVID-19 3CL protease using molecular docking and machine learning regression approaches. [PDF]

Sci Rep
Aqeel I, Majid A, Albanyan A, Wasfi H.
europepmc   +1 more source

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4‐regulated ferroptosis

Animal Models and Experimental Medicine, EarlyView.
BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen, Rui‐Rui Gao, Yan‐Yan Chen, Yi‐Jie Wang, Xin‐Tong Wang, Hai‐Xin Liu   +5 more
wiley   +1 more source

Immunotoxicity Study of Cucurbit[n]urils (n = 6, 7, 8) and Modeling of Interaction with Some Monocyte Receptors by a Molecular Docking Method. [PDF]

Molecules
Zhautikova SB, Abdykhanova NN, Fedorishin DA, Shapovalova YG, Khlebnikov AI, Bakibaev AA, Kurzina IA, Kabieva SK, Boranbay N, Zhumanazarova GM.   +9 more
europepmc   +1 more source

Yunweiling alleviates functional constipation: integrating network pharmacology and experimental study

Animal Models and Experimental Medicine, EarlyView.
In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang, Wei Li, Weiwen Zheng, Jinwen Liu, Nuonan She, Xia Chen, Weibo Wen   +6 more
wiley   +1 more source

Identification of Novel HPK1 Hit Inhibitors: From In Silico Design to In Vitro Validation. [PDF]

Int J Mol Sci
Isawi IH, Obeidat RM, Alnabulsi S, Al Zoubi R.   +3 more
europepmc   +1 more source

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Animal Models and Experimental Medicine, EarlyView.
The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie   +9 more
wiley   +1 more source

Investigation of the inhibitory potential of secondary metabolites isolated from Fernandoa adenophylla against Beta-glucuronidase via molecular docking and molecular dynamics simulation studies. [PDF]

PLoS One
Rauf A, Ajaj R, Akram Z, Khan M, Wadood A, Zulfat M, Shah ZA, Alamri AS, Alsanie WF, Alhomrani M, Hussain H, Formanowicz D.   +11 more
europepmc   +1 more source

Mechanistic insights into Sanbi Decoction for osteoarthritis treatment based on network pharmacology and experimental validation. [PDF]

Sci Rep
Huang Z, Jiang X, Xie W, Wei K, Yang L, Liu D, Zhong L.   +6 more
europepmc   +1 more source

Combining kinetics and in silico approaches to evaluate bromhexine as an anti-pancreatic lipase agent for obesity management. [PDF]

Sci Rep
Gholami A, Minai-Tehrani D, Eriksson LA.
europepmc   +1 more source

Exploration of Liuwei Dihuang Pill on periodontitis based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Luo Y, Liu C, Liu J, Wang H, Fu Y, Liu Y.   +5 more
europepmc   +1 more source