Results 311 to 320 of about 2,926,121 (366)

Design, Synthesis, and Docking Study of Pyrimidine–Triazine Hybrids for GABA Estimation in Animal Epilepsy Models

Archiv der Pharmazie, 2017
A series of new pyrimidine–triazine hybrids (4a–t) was designed and synthesized, from which potent anticonvulsant agents were identified. Most of the compounds exhibited promising anticonvulsant activity against the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests, along with minimal motor impairment with higher safety ...
Meeta Sahu, Nadeem Siddiqui, Mohd. Javed Naim, Ozair Alam, Mohammad Shahar Yar, Vidushi Sharma, Sharad Wakode   +6 more
semanticscholar   +5 more sources

Assessment of palmitic acid toxicity to animal hearts and other major organs based on acute toxicity, network pharmacology, and molecular docking

Computers in Biology and Medicine, 2023
Palmitic acid is a common ingredient in many foods and traditional Chinese medicines. However, modern pharmacological experiments have shown that palmitic acid has toxic side effects. It can damage glomeruli, cardiomyocytes, and hepatocytes, as well as promote the growth of lung cancer cells. Despite this, there are few reports evaluating the safety of
Lijuan, Lv, Xiangpei, Wang, Hongmei, Wu
semanticscholar   +4 more sources

Promising Anti-stroke Signature of Voglibose: Investigation through In- Silico Molecular Docking and Virtual Screening in In-Vivo Animal Studies

Current Gene Therapy, 2020
Background: Postprandial hyperglycemia considered to be a major risk factor for cerebrovascular complications. Objective: The current study was designed to elucidate the beneficial role of voglibose via in-silico in vitro to in-vivo studies in improving the postprandial glycaemic state by protection against strokeprone type 2 diabetes.
Snehal S. Patel, Shraddha V. Bhadada, Ghulam Md Ashraf, Vishal Chavda, Pooja Shah   +4 more
semanticscholar   +4 more sources

α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study

Chemico-Biological Interactions, 2016
The anti-hyperalgesic effect of the complex containing α-terpineol (αTPN) and β-cyclodextrin (βCD) was analyzed in a non-inflammatory chronic muscle pain model, as well as its mechanism of action through docking study for a possible interaction with receptors.
Heitor G. Araújo-Filho, Parimelazhagan Thangaraj, Marcus Tullius Scotti, Renan G. Brito, Paula dos Passos Menezes, Priscila L. Santos, Lucindo José Quintans-Júnior, Jullyana S.S. Quintans, Yasmim Maria Barbosa Gomes de Carvalho, Saravanan Shanmugam, Luciana Scotti, Adriano Antunes de Souza Araújo, Mairim Russo Serafini, Juliane Cabral Silva, Jackson Roberto Guedes da Silva Almeida, Makson G. B. Oliveira   +15 more
semanticscholar   +5 more sources

The long and short of it: A review of tail docking in farm animals

Applied Animal Behaviour Science, 2011
Tail docking involves amputating a portion of the tail for a variety of reasons. We review the scientific evidence for the rationale for tail docking, a description of the different methods used, the pain response to the procedure and the effectiveness of pain alleviation, and, finally, the alternatives to tail docking and policy regarding the practice.
Mhairi A. Sutherland, Cassandra B. Tucker   +1 more
openaire   +3 more sources

Exploring the potential mechanism of Yixiang capsule immune-enhancing function based on Network Pharmacology, Molecular docking, and Animal function experiment

Combinatorial Chemistry & High Throughput Screening, 2022
Background: The Yixiang capsule with traditional Chinese herbs Cistanches Herba, Hedysarum multijugum Maxim,Fructus Ligustri Lucidi,and Fructus lycii are the main raw materials in a modern herbal medicine preparation containing corresponding bioactive ingredients after extraction and processing.
Jing, Wang, Weirong, Bai, Yan, Ding, Chenchen, Deng, Zhenzhong, Wang, Wei, Xiao   +5 more
openaire   +3 more sources

UPLC-Q-TOF-MS/MS Combined with Network Pharmacology, Molecular Docking, and Animal Verification Reveals the Mechanism of Insomnia Treatment by Shen Qi Wu Wei Zi Capsules

Combinatorial Chemistry & High Throughput Screening, 2023
Background: Shen Qi Wu Wei Zi capsules (SQWWZ) are often used to treat insomnia; however, the potential therapeutic mechanism is still unclear. Objective: This study aimed to investigate the mechanism underlying the therapeutic effects of the Shen Qi Wu Wei Zi capsules on insomnia.
Fengyun, Bai, Jie, Wang, Ning, Xia, Ying, Sun, Yundong, Xie, Chongbo, Zhao, Jing, Sun, Xiaofei, Zhang   +7 more
openaire   +3 more sources

Docking analysis of circulating CTX-M variants in multi-drug resistant, beta-lactamase and biofilm-producing E. coli isolated from pet animals and backyard livestock

Microbial Pathogenesis, 2022
The generation of antimicrobial-resistant bacteria largely depends on the use of antimicrobials not only in humans but also in pet animals and livestock. The present study was conducted to detect the occurrence of beta-lactamase and biofilm-producing- E.coli in healthy pet and backyard livestock. The study also intended on molecular docking experiments
Abhiroop Banerjee, Surajit Pal, Purba Goswami, Kunal Batabyal, Siddhartha Narayan Joardar, Samir Dey, Devi Prasad Isore, Tapan Kumar Dutta, Samiran Bandyopadhyay, Indranil Samanta   +9 more
openaire   +3 more sources

Identification and molecular mechanism of the anti-inflammatory effect of sea cucumber peptides: Network pharmacology, molecular docking and animal experiments

International Journal of Biological Macromolecules
Ulcerative colitis (UC) is a chronic inflammatory bowel disease for which there is currently no efficacious therapeutic drug with fewer side effects. Therefore, the development of approaches for the prevention of UC from natural food sources is urgently needed. In this study, mice were pre-fed with sea cucumber peptides prior to dextran sodium sulfate (
Jianhui, Feng, Haojie, Wang, Xinyue, Luo, Lina, Zhang, Peng, Zhou   +4 more
openaire   +3 more sources