Results 101 to 110 of about 144,720 (214)

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source

In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma

Advanced Science, EarlyView.
By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He, Duo Yu, Fei Xie, Kaisheng Hou, Zhaozhao Li, Meifang Dai, Jingyi Yun, Haiyan Cao, Yang Xiao, Yueyuan Qiu, Gege Shi, Wangqian Zhang, Shuning Wang, Qiang Hao, Jieyu Zhang, Zhaowei Wang, Yingqi Zhang, Kuo Zhang, Jintao Gu, Haichen Du, Meng Li   +20 more
wiley   +1 more source

Entrustment in Doctor-Patient Communication in Family Medicine Training - a Systematic Review of the Literature. [PDF]

Adv Med Educ Pract
Silva-Monteiro J, Ribeiro L, Santos P.
europepmc   +1 more source

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Teaching Personalized Doctor-Patient Communication with AI: PerTRAIN - a Prototype for Interpersonally Responsive Virtual Patients in Medical Education. [PDF]

Perspect Med Educ
Junga A, Hätscher O, Dabel J, Mado G, Ajani A, Pielage L, Kockwelp P, Breil SM, Baur H, Siebenbrock J, Risse B, Grammer T, Marschall B, Back MD.   +13 more
europepmc   +1 more source

Loss of Lepr in Fibroblasts Drives Tumor Development by Promoting Macrophage Infiltration

Advanced Science, EarlyView.
TNFα and TGFβ signaling reprograms Lepr+ fibroblasts toward a LeprnegMmphigh inflammatory CAF (iCAF) state, with downregulation of the Tcf21‐Lepr axis contributing to this transition. Lepr loss induces Csf3, which contributes to the enhanced macrophage‐recruiting capacity of these iCAFs, thereby promoting tumor development. Thus, inflammatory signaling
Manyu Song, Wuqi Yang, Bangran Qi, Liyuan Hou, Xu Yang, Jiuzhi Xu, Shengyuan Tian, Shuiling Jin, Lu Yu, Zhengquan Yu, Min Deng, Jiaqiang Huang, Suoqin Jin, Cong Lv   +13 more
wiley   +1 more source

DischargeSim: A Simulation Benchmark for Educational Doctor-Patient Communication at Discharge. [PDF]

Proc Conf Empir Methods Nat Lang Process
Yao Z, Sun M, Jang WS, Kwon S, Kwon S, Yu H.   +5 more
europepmc   +1 more source

An analytic hierarchy process analysis for reinforcing doctor-patient communication. [PDF]

BMC Prim Care, 2023
Park S, Kim HK, Lee M.
europepmc   +1 more source

Improving Post‐Fall Assessment Documentation in Older Inpatients Using a Structured Falls Proforma: A Retrospective Cohort Study

AGING MEDICINE, EarlyView.
Falls among hospital inpatients are associated with significant morbidity and require comprehensive post‐fall assessment. This retrospective cohort study evaluated documentation completeness following inpatient falls in older adults and compared assessments completed using a structured Falls Proforma with standard documentation methods.
Ella V. Brockwell‐Mole, Dujinthan Jayabalan, Su Kitchen, Minoti Bhagat   +3 more
wiley   +1 more source

Assessment of knowledge, attitude, and practices of Lebanese diabetic patients and their relation to medication adherence and doctor-patient communication: A cross-sectional study. [PDF]

J Public Health Res
Fahs H, Mansour S, Dakroub D, Hammoud J, Ibrahim A, Rida A, Kassem NM, El Khatib S, Shrayteh Z, Obeid S, Younes S, Rahal M, Sakr S, Hallit S, Malaeb D, Hosseini H.   +15 more
europepmc   +1 more source