Results 181 to 190 of about 13,563,024 (303)

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

When supervisor support is not enough: the roles of impostor syndrome and neuroticism in academic procrastination among doctoral students in China. [PDF]

Front Psychiatry
Yang X, Zhang C, Xu M, Yeo KJ, Liu Y.
europepmc   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Investigating PhD students' wellbeing and mental health: towards evidence-led and innovative solutions. [PDF]

Front Psychol
Vecchio R, Mosconi G, Gandola M, Amerio A, Odone A, Health Mode On Investigators, Albini G, Barbati C, Barone L, Baroni M, Bertuccio P, Brunelli L, Brusaferro S, Carli A, Casigliani V, Crescentini C, Diadema E, Emdin M, Faggiano F, Fedeli D, Fossati A, Lecce S, Mehanović E, Mosconi G, Ogliari A, Odone A, Pennucci F, Quattrone F, Raglio A, Rizzo C, Rossi E, Tobia V, Vecchio R, Pietro Vigezzi G, Vigna-Taglianti F, Vivaldi E, Viviani L, Zeppegno P, Zingarelli M, Zizza C.   +39 more
europepmc   +1 more source

Hierarchical Physical‐Cyber Encryption via Metasurface‐Encoded Holographic Keys

Advanced Science, EarlyView.
ABSTRACT Physical‐layer encryption based on metasurfaces has emerged as a promising alternative to conventional algorithmic cryptography by embedding security into physical processes. However, most existing metasurface‐based encryption schemes operate within single‐stage or static frameworks, where correct physical illumination directly reveals the ...
Zhen Liu, Changhong Dai, Wei Zhu, Ruisheng Yang, Bohan Zhang, Lei Zhang, Bobo Du, Shengxiang Wang, Guangwei Hu   +8 more
wiley   +1 more source

Exploring the influencing factors of academic doctoral students' academic innovation behavior in the context of generative artificial intelligence: Self-determination theory and motivation-opportunity-ability perspectives. [PDF]

PLoS One
Liu Y, Zhang M, Peng Y.
europepmc   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Doctor of Philosophy (PhD) in Orthopaedics: Barriers, Challenges, and Opportunities in Education and Research. [PDF]

J Orthop Case Rep
Bharadwaj S, Jeyaraman N, Jeyaraman M, Shyam A.   +3 more
europepmc   +1 more source

Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States

Advanced Science, EarlyView.
Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton, Carrillo Paola Gonzalez, Luay Almassalha, Wing Shun Li, Ruyi Gong, Nicolas Acosta, I Chae Ye, Jane Frederick, Christopher Hogg, Saira John, J. A. Gareth Williams, Rikkert J. Nap, Igal Szleifer, Vadim Backman   +13 more
wiley   +1 more source

Academic motivation and burnout among Chinese doctoral students: the mediating role of academic resilience and the moderating role of perceived stress. [PDF]

Front Psychol
Zhao G.
europepmc   +1 more source