Results 51 to 60 of about 13,563,024 (303)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Digital Leadership and Innovation in Indonesia’s Public Administration: Insights from the Govtech INA Digital Reform

International Journal of Social Science and Religion
This study explores how digital leadership influences innovation in Indonesia’s public sector amid the nationwide implementation of GovTech INA Digital and the updated Electronic Based Government System (SPBE).
Ariawan, Triyuni Soemartono, Khasan Effendy, Pandji Sukmana   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

CO-CREATION AND THE CREATIVE ECONOMY : REDEFINING PUBLIC SERVICE DELIVERY FOR INCLUSIVE INNOVATION

Journal of Management Small and Medium Enterprises (SME's)
The creative economy has emerged as a dynamic engine of economic resilience and social innovation, especially in the aftermath of the COVID-19 pandemic.
Dessy Ruhati, Triyuni Soemartono, Khasan Effendy, T. Herry Rachmatsyah   +3 more
doaj   +1 more source

The Doctoral Student’s Responsibility for Violation of Ethical Standards During Doctoral Studies

EIRP Proceedings, 2022
Intellectual property law enjoys the most expansive and branching evolution of the last century, both in terms of national regulations and in terms of signed international conventions and adopted Community directives, as evidenced even by established ...
Maria Cristiana Ieremie
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Policy Diffusion, Digitalisation, and Governance Gaps in the Implementation of Indonesia's Golden Visa Programme

Journal of Global Strategic Studies
Indonesia’s Golden Visa, launched in 2023 through Minister of Law and Human Rights Regulation No. 22/2023, is promoted as a residence-by-investment scheme to attract foreign capital and talent for post-pandemic recovery and digital transformation.
Gunawan Ari Nursanto, Sunarto Sunarto, Pandji Sukmana, Gatot Hery Djatmiko   +3 more
doaj   +1 more source

Doctoral studies as a precarious identity process: deviance and the rational ideal of the doctoral process

Based on narrative interviews with late-phase doctoral candidates and early postdoctoral researchers, complemented by an autoethnographic diary, this study analyses the experiences of junior academics.
Blomberg, Annika
core   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Digitalisation of Border Control through Autogate and the Emerging Configuration of Immigration System Resilience in Indonesia

International Journal of Social Science and Religion
This article examines Indonesia’s autogate policy not only as a digital service innovation, but as a component of immigration system resilience. Drawing on policy implementation theory by Edwards III, Sabatier & Mazmanian, e-government literature on the
Besse Hartati, Sunarto, Pandji Sukmana, T. Herry Rachmatsyah   +3 more
doaj   +1 more source