Results 131 to 140 of about 2,229,911 (330)

Clinical and Radiographic Predictors of Deterioration in Mild Cervical Spondylotic Myelopathy

Philippine Journal of Orthopaedics
Background and Objectives. The management approach for mild cervical spondylotic myelopathy (CSM) is still unclear, and the decision to perform outright surgery remains a topic of debate.
Jose Kreisher Rae Foscablo, John David Mata, Immanuel Silverio, Ronald Tangente   +3 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Letter to the Occupy Movement: Freeing Our Physicians

Social Medicine, 2012
Open letter from members of Doctors for the 99% and Healthcare for the 99% to the greater Occupy community.
Noriyuki Murakami, Amit Patel, Magni Hamso, Avra Ackerman   +3 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The attitudes, knowledge and practices of Maltese family doctors in disease prevention and health promotion [PDF]

, 2014
Introduction: Family doctors are in a unique position to advocate health promotion and disease prevention, though it is known that this is not always given its due importance due to various reasons.
Gauci, Charmaine, Pace, Lynn, Sammut, Mario R.   +2 more
core  

Doctor doctor jokes

Faculty Dental Journal, 2014
Not a laughing matter, apparently.
openaire   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Digital health for Tuberculosis control: findings from the piloting of an electronic medical record in Luanda (Angola)

BMC Medical Informatics and Decision Making
Background Digital health, like the use of electronic medical records (EMR), has been highlighted as a potential avenue to improve Tuberculosis (TB) surveillance and treatment outcomes.
Claudia Robbiati, Maria Elena Tosti, Joaquim Tomas, Giulia Natali, Luca De Simeis, Nsuka Da Silva, Florentino Ferraz Joaquim, Daniel Tulomba, Neusa Lazary, Janet Adão, Fabio Manenti, Maria Grazia Dente   +11 more
doaj   +1 more source

New Directions for Minority Enterprise [PDF]

, 1971
Doctors, Samuel I., Lockwood, Sharon
core   +3 more sources