Results 31 to 40 of about 14,919 (253)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

NFDI MatWerk Ontology (MWO): A BFO‐Compliant Ontology for Research Data Management in Materials Science and Engineering

Advanced Engineering Materials, EarlyView.
This article presents the NFDI‐MatWerk Ontology (MWO), a Basic Formal Ontology‐based framework for interoperable research data management in materials science and engineering (MSE). Covering consortium structures, research data management resources, services, and instruments, MWO enables semantic integration, Findable, Accessible, Interoperable, and ...
Hossein Beygi Nasrabadi, Ebrahim Norouzi, Kostiantyn Hubaiev, Jörg Waitelonis, Harald Sack   +4 more
wiley   +1 more source

Policy analysis of system responses to addressing and reversing the obesity trend in China: a documentary research

BMC Public Health, 2023
Background The obesity epidemic and its established consequences on population health and the economy call for a vigorous fight against excess weight. The primary aim of this study is to investigate China’s responses to address and reverse the obesity ...
Yan Xue, Zhen Ruan, Carolina Oi Lam Ung, Yunfeng Lai, Hao Hu   +4 more
doaj   +1 more source

PASTA‐ELN: Simplifying Research Data Management for Experimental Materials Science

Advanced Engineering Materials, EarlyView.
Research data management faces ongoing hurdles as many ELNs remain complex and restrictive. PASTA‐ELN offers an open‐source, cross‐platform solution that prioritizes simplicity, offline access, and user control. Its in tuitive folder structure, modular Python add‐ons, and open formats enable seamless documentation, FAIR data practices, and easy ...
S. Brinckmann, G. Winkens, R. Schwaiger
wiley   +1 more source

GenAI-Assisted Database Deployment for Heterogeneous Indigenous–Native Ethnographic Research Data

Applied Sciences
In ethnographic research, data collected through surveys, interviews, or questionnaires in the fields of sociology and anthropology often appear in diverse forms and languages.
Reen-Cheng Wang, David Yang, Ming-Che Hsieh, Yi-Cheng Chen, Weihsuan Lin   +4 more
doaj   +1 more source

A METHODOLOGICAL APPROACH FOR AN AUGMENTED HBIM EXPERIENCE THE ARCHITECTURAL THRESHOLDS OF THE MOSTRA D'OLTREMARE [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Digital survey and parametric-semantic modeling of historical or conventional building artifacts are becoming progressively more oriented toward HBIM (Heritage Building Information Modelling) to XR (Extended Reality) digital fruition projects.
G. Antuono, E. Elefante, P. G. Vindrola, P. D’Agostino   +3 more
doaj   +1 more source

Functional Requirements for Medical Data Integration into Knowledge Management Environments: Requirements Elicitation Approach Based on Systematic Literature Analysis

Journal of Medical Internet Research, 2023
BackgroundIn patient care, data are historically generated and stored in heterogeneous databases that are domain specific and often noninteroperable or isolated.
Benjamin Kinast, Hannes Ulrich, Björn Bergh, Björn Schreiweis   +3 more
doaj   +1 more source

a Schema Extraction of Document-Oriented Database for Data Warehouse

International Journal on Information and Communication Technology (IJoICT), 2021
The data warehouse is a very famous solution for analyzing business data from heterogeneous sources. Unfortunately, a data warehouse only can analyze structured data. Whereas, nowadays, thanks to the popularity of social media and the ease of creating data on the web, we are experiencing a flood of unstructured data.
A. Nurul Istiqamah, Kemas Rahmat Saleh Wiharja   +1 more
openaire   +2 more sources