Identifying prognostic targets in metastatic prostate cancer beyond AR
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng+13 more
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A sociotechnical approach to defining clinical responsibilities for patient-generated health data. [PDF]
Griffin AC+4 more
europepmc +1 more source
Before Lewis and Clark: Documents Illustrating the History of the Missouri, 1785-1804
Bernard DeVoto, A. P. Nasatir
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The Post Office of fifty years ago : containing reprint of Sir Rowland Hill's famous pamphlet, dated 22nd February, 1837, proposing penny postage : with facsimile of the original sketch for the postage stamp, and other documents [PDF]
Pearson Hill, Rowland Hill
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The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo+4 more
wiley +1 more source
Help us document what we already do: pilot study of clinical decision support tools targeting social risk-informed care. [PDF]
Pisciotta M+9 more
europepmc +1 more source
The Quest and Occupation of Tahiti by Emissaries of Spain during the Years 1772-1776, told in Despatches and other Contemporary Documents [PDF]
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