Results 91 to 100 of about 1,094,003 (307)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A consultation on new procurement and delivery arrangements for the schools’ estate in Northern Ireland [PDF]

, 2005
"... the Department of Education and the Strategic Investment Board Ltd (SIB) jointly commissioned consultants (PricewaterhouseCoopers) to review the existing procurement and delivery arrangements for managing the schools’ estate and to identify areas

core  

Software Infrastructure for Natural Language Processing

, 1997
We classify and review current approaches to software infrastructure for research, development and delivery of NLP systems. The task is motivated by a discussion of current trends in the field of NLP and Language Engineering.
Cunningham, Hamish, Gaizauskas, Robert, Humphreys, Kevin, Wilks, Yorick   +3 more
core   +4 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Content Access via Resource Sharing Early in the COVID-19 Pandemic: Findings from Nine Health Science Libraries

Issues in Science and Technology Librarianship
Objective  COVID-19 challenged information exchanged globally, including interlibrary loan (ILL) procedures and processes. This research focused on resource-sharing networks used by Health Sciences Libraries (HSL) before and during the COVID-19 ...
Jenny Pierce, Caitlin Bakker, Phill Jo, Jeannine Creazzo, Holly Thompson, Kristine Alpi   +5 more
doaj   +1 more source

Scalable Routing Easy as PIE: a Practical Isometric Embedding Protocol (Technical Report) [PDF]

, 2013
We present PIE, a scalable routing scheme that achieves 100% packet delivery and low path stretch. It is easy to implement in a distributed fashion and works well when costs are associated to links. Scalability is achieved by using virtual coordinates in
Herzen, Julien, Thiran, Patrick, Westphal, Cedric   +2 more
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Document Delivery and Its Status in Iran and Around the World

Iranian Journal of Information Processing & Management, 2007
For a long time, and especially in the past two decades, Information acquisition had been and still is affected by limiting factors such as the huge volume of publications, space shortages and financial constrictions.
Maryam Khosravi, Amirhossein Abdulmajid
doaj  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Advanced Transport Operating System (ATOPS) color displays software description: MicroVAX system [PDF]

This document describes the software created for the Display MicroVAX computer used for the Advanced Transport Operating Systems (ATOPS) project on the Transport Systems Research Vehicle (TSRV).
Dickson, Richard W., Plyler, Valerie E., Slominski, Christopher J.   +2 more
core   +1 more source