Results 101 to 110 of about 39,490,265 (332)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Hybrid Object Detection and Semantic Segmentation for Offline Handwritten Diagram Understanding
IEEE AccessThis work addresses the problem of offline handwritten diagram understanding by proposing a hybrid framework that integrates object detection, semantic segmentation, and optical character recognition (OCR) to reconstruct the complete topological ...
Daniela De Sousa Costa +1 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Image analysis in technical documentation
, 2019 In the era of Big Data, manufacturing companies are overwhelmed by a lot of disorganized information: the large amount of digital content that is increasingly available in the manufacturing process makes the retrieval of accurate information a critical issue.
Carrara F, Debole F, Gennaro C, Amato G
openaire +4 more sources
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Human Interactive Proofs and Document Image Analysis [PDF]
, 2002 The recently initiated and rapidly developing research field of 'human interactive proofs' (HIPs) and its implications for the document image analysis (DIA) research field are described. Over the last five years, efforts to defend Web services against abuse by programs ('bots') have led to a new family of security protocols able to distinguish between ...
Henry S. Baird, Kris Popat
openaire +2 more sources
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Modern Trends in Hyperspectral Image Analysis: A Review
IEEE Access, 2018 Over the past three decades, significant developments have been made in hyperspectral imaging due to which it has emerged as an effective tool in numerous civil, environmental, and military applications. Modern sensor technologies are capable of covering
M. J. Khan +4 more
semanticscholar +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
HeritageAncient documents that have undergone physical and visual degradation pose significant challenges in the digital recognition and preservation of information.
Imam Yuadi +5 more
doaj +1 more source