Results 41 to 50 of about 64,341 (260)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An enhanced binarization framework for degraded historical document images

open access: yesEURASIP Journal on Image and Video Processing, 2021
Binarization plays an important role in document analysis and recognition (DAR) systems. In this paper, we present our winning algorithm in ICFHR 2018 competition on handwritten document image binarization (H-DIBCO 2018), which is based on background ...
Wei Xiong   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Deep Learning Method for Handwriting Recognition

open access: yesMANAS: Journal of Engineering, 2021
The advancement of technology nowadays resulted into documents, such as forms and petitions, being filled out in computer and digital environment. Yet in some cases, documents are still preserved in traditional style, on print.
Abdullah Erdal Tümer   +1 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Comparative Semantic Document Layout Analysis for Enhanced Document Image Retrieval

open access: yesIEEE Access
Tons of handwritten document images, either historical or continuously reproduced in everyday life, are information-rich, awaiting extensive advanced technological attention from academic and industrial communities.
Emad Sami Jaha
doaj   +1 more source

Intelligent classification on images of Dongba ancient books

open access: yesThe Journal of Engineering, 2019
Dongba hieroglyphs are the only living hieroglyphs in the world today and are still used by people. The various ritual activities in Dongba culture are passed down through the Dongba hieroglyphs in the form of books. In view of the current classification
Ruxiang Hua, Xiaoli Xu
doaj   +1 more source

A GRASS GIS Scripting Framework for Monitoring Changes in the Ephemeral Salt Lakes of Chotts Melrhir and Merouane, Algeria

open access: yesApplied System Innovation, 2023
Automated classification of satellite images is a challenging task that enables the use of remote sensing data for environmental modeling of Earth’s landscapes.
Polina Lemenkova
doaj   +1 more source

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