Results 81 to 90 of about 35,997 (299)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

UniText: A Unified Framework for Chinese Text Detection, Recognition, and Restoration in Ancient Document and Inscription Images

Applied Sciences
Processing ancient text images presents significant challenges due to severe visual degradation, missing glyph structures, and various types of noise caused by aging.
Lu Shen, Zewei Wu, Xiaoyuan Huang, Boliang Zhang, Su-Kit Tang, Jorge Henriques, Silvia Mirri   +6 more
doaj   +1 more source

Stakeholder Group Reaches Agreement in Historic Forest Restoration Effort [PDF]

, 2010
Flagstaff, Ariz. – After working together for a year, community leaders, governmental organizations, environmentalists, scientists, and private industry leaders have reached agreement on a proposed course of action to restore health to Arizona’s degraded
Stevens, B.
core  

Electronic document management system analysis report and system plan for the Environmental Restoration Program

, 1995
Lockheed Martin Energy Systems, Inc. (LMES) has established and maintains Document Management Centers (DMCs) to support Environmental Restoration Program (ER) activities undertaken at three Oak Ridge facilities: Oak Ridge National Laboratory, Oak Ridge K-
Frappaolo, C.
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The perceived ecological and human well‐being benefits of ecosystem restoration

People and Nature
Traditionally, ecosystem restoration has focussed on standard ecological indicators like water or habitat quality, species population abundance or vegetation cover to determine success.
Matthew Jurjonas, Christopher A. May, Bradley Cardinale, Stephanie Kyriakakis, Douglas R. Pearsall, Patrick J. Doran   +5 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A documentation study of the restoration process of Al-Haddam heirs’ house in Bab Zir – Tlemcen city in western Algeria

Revista de Expresión Gráfica en la Edificación
The old city of Tlemcen, west of Algeria, has received many restoration projects, including various architectural monuments and archaeological sites dating back to different periods of time, especially those that the city witnessed on its selection as ...
Othman Yebdri, Labtar Qadda
doaj   +1 more source

DocRevive: A Unified Pipeline for Document Text Restoration

CoRR
In Document Understanding, the challenge of reconstructing damaged, occluded, or incomplete text remains a critical yet unexplored problem. Subsequent document understanding tasks can benefit from a document reconstruction process. In response, this paper presents a novel unified pipeline combining state-of-the-art Optical Character Recognition (OCR ...
Kunal Purkayastha, Ayan Banerjee 0002, Josep Lladós 0001, Umapada Pal 0001   +3 more
openaire   +2 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source