Results 101 to 110 of about 5,946,252 (278)

Manitoba First Nations Casino Project : request for proposals

, 2000
Within a solid framework, First Nations gaming can create opportunities for the host community and adjacent communities, for First Nations people and for the Province of Manitoba as a whole.
Selection Committee. Manitoba First Nations Casino Project
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A New Filter Feature Selection Method for Text Classification

IEEE Access
Massively amounts of text data have been created on the Internet due to the widespread use of platforms like social media. Text classification is one of the most frequently used techniques for extracting useful information from text data. One of the most
Rasim Cekik
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The Living Document : Medical Records as a Malleable Presence [PDF]

Understanding why individuals might safeguard information or keep secrets in working documents such as medical records is essential for the development of good quality care, fostering an environment where both patients and staff feel secure to part with ...
Lyckblad, Camilla
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A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cost Analysis and Long Term Planning Over the Lifecycle of an Enterprise Storage Solution

Journal of Technology Management & Innovation, 2006
This document will cover the basics of Storage Area Networks (SAN), IP-Based Storage Networks such as NAS, and the basics of choosing a technology for an Enterprise Storage infrastructure.
Christopher J. McKnight
doaj  

Evaluating LLMs on document-based QA: Exact answer selection and numerical extraction using CogTale dataset

Natural Language Processing Journal
Document-based Question-Answering (QA) tasks are crucial for precise information retrieval. While some existing work focus on evaluating large language model’s (LLMs) performance on retrieving and answering questions from documents, assessing the LLMs ...
Zafaryab Rasool, Stefanus Kurniawan, Sherwin Balugo, Scott Barnett, Rajesh Vasa, Courtney Chesser, Benjamin M. Hampstead, Sylvie Belleville, Kon Mouzakis, Alex Bahar-Fuchs   +9 more
doaj   +1 more source

A New Approach for Text Documents Classification with Invasive Weed Optimization and Naive Bayes Classifier [PDF]

Journal of Advances in Computer Engineering and Technology, 2018
With the fast increase of the documents, using Text Document Classification (TDC) methods has become a crucial matter. This paper presented a hybrid model of Invasive Weed Optimization (IWO) and Naive Bayes (NB) classifier (IWO-NB) for Feature Selection (
Saman Khalandi, Farhad Soleimanian Gharehchopogh   +1 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source