Results 131 to 140 of about 5,946,252 (278)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Subscribing to Supplemental Health Insurance in France: A Dynamic Analysis of Adverse Selection [PDF]

Adverse selection, which is well described in the theoretical literature on insurance, remains relatively difficult to study empirically. The traditional approach, which focuses on the binary decision of “covered” or “not”, potentially misses the main ...
Aurélie Pierre, Marc Perronnin, Carine Franc   +2 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Artificial intelligence-driven study selection in systematic reviews of randomized controlled trials, emulated trials and economic evaluation studies using large language models. [PDF]

PLOS Digit Health
Looareesuwan P, Ponthongmak W, Tansawet A, Ratanatharathorn C, Owasi HUR, McKay GJ, Attia J, Oami T, Thakkinstian A.   +8 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Large Language Model-guided Document Selection [PDF]

Large Language Model (LLM) pre-training exhausts an ever growing compute budget, yet recent research has demonstrated that careful document selection enables comparable model quality with only a fraction of the FLOPs.
Pang, Ruoming, Gunter, Tom, Kong, Xiang
core   +1 more source

Vector Flow Imaging for Carotid Artery Stenosis Assessment: A Scoping Review. [PDF]

Diagnostics (Basel)
Henriksen AC, Baarts R, Panduro NS, Bengtsson EKE, Zetner D, Lönn L, Sørensen CM, Jensen JA, Nielsen MB.   +8 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Budget-Aware Routing for Long Clinical Text. [PDF]

Find ACL ACL
Qureshi K, Martin G, Peng Y.
europepmc   +1 more source