Results 121 to 130 of about 13,127 (242)

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

open access: yesAging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef   +2 more
wiley   +1 more source

FET y de las JONS en el món rural català de la postguerra

open access: yesSegle XX, 2014
L’article analitza el desplegament de FET y de las JONS en el món rural de l’interior de Catalunya durant la postguerra. Des d’una metodologia que prioritza l’estudi arran de terra i el tractament de les fonts documentals provincials i locals, es ...
Josep Gelonch Solé
doaj  

La biblioteca de formació del professorat d'Elx [PDF]

open access: yes, 2015
S'explica una breu història de la B-CD de Formació del Professorat d'Elx des del seu naixement, fa 30 anys, com a Biblioteca del CEP d'Elx, fins a la actualitat com a extensió del CEFIRE d'Alacant. Mantenint una missió invariable al llarg de tots aquests
Martínez Teva, Clara E.
core  

Documents/documentation

open access: yes, 2017
Documentation – that is, documents and practices with them (or documentary practices) – plays a central role in constituting and materializing information. Bernd Frohmann (2004) argues that information is an effect of documentation. He argues that attention to documents and documentary practices “reveals how it is that particular documents, at ...
openaire   +1 more source

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu   +5 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi   +2 more
wiley   +1 more source

Els dipòsits documentals i la iniciativa d’arxius oberts a Amèrica Llatina

open access: yesBiD: Textos Universitaris de Biblioteconomia i Documentació, 2008
En l'actualitat hi ha pocs estudis sobre la realitat dels dipòsits documentals i les biblioteques digitals llatinoamericanes; a més, les anàlisis sobre la implantació de la iniciativa d'arxius oberts i el protocol de recollida de metadades OAI-PMH són ...
Gómez Dueñas, Laureano Felipe
doaj  

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein   +13 more
wiley   +1 more source

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