Results 51 to 60 of about 14,830 (269)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Proposal for a documentary structure of a quality management system for the production area of ​​All service rhyno S.A.S

open access: yes, 2022
A través de la respectiva pasantía, se plantea como principal objetivo la realización de una propuesta a través de la cual se pueda contar con una estructura documental de un sistema de gestión de la calidad (Sistema el cual no se encuentra implementado ...
Ipus Leguizamón, Kevin Esteban   +1 more
core  

THE PRIVATE CONSULTANCY IN EDUCATION MANAGEMENT AT CAMPINAS EDUCATION PUBLIC SYSTEM

open access: yesEducação: Teoria e Prática, 2016
This article aims at contributing to the comprehension of current managerial reforms that reconfigure the public administration. Within the agreement signed in 2013 between the Municipality of Campinas and Comunitas organization, we analyze specifically ...
Sara Badra de Oliveira
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Invest to Save: Report and Recommendations of the NSF-DELOS Working Group on Digital Archiving and Preservation [PDF]

open access: yes, 2003
Digital archiving and preservation are important areas for research and development, but there is no agreed upon set of priorities or coherent plan for research in this area.
Hedstrom, M.   +9 more
core  

Duties and Required Competencies of a Management Contractor

open access: yesJournal of Construction Business and Management, 2018
One of the responses to the critical failings of separation of design and construction processes of traditional procurement system is the development of management contracting (MC) procurement system.
Calistus Ayegba
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Herramientas de software libre para la gestión de contenidos = Open source tools for content management [PDF]

open access: yes, 2005
Information and documentation services available on the Internet through web servers are growing in an exponential manner. The logical evolution of the Internet over the last 10 years has been producing a replacement of static web pages and documents by ...
Tramullas, Jesús   +2 more
core  

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