Results 91 to 100 of about 5,207,695 (291)

Finding the key transition states and intermediates controlling net reaction rates and selectivity [PDF]

, 2011
In this paper Campbell's degree of rate control is extended to introduce the concepts of degree of kinetic rate control, degree of kinetic selectivity control, degree of thermodynamic rate control and degree of thermodynamic selectivity control.
Anders Andreasen, Carsten Stegelmann
core   +2 more sources

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Vologda Congress of Political Exiles in 1907: Local Authorities and Self-Organization of the Revolutionaries

Historia provinciae: журнал региональной истории
The article analyzes the problem of relationships among local administrators who discussed the issue of political exiles in Vologda Governorate. The author studies the situation (unique in many respects) that occurred in Vologda Governorate in the fall ...
Pavel V. Tikhomirov
doaj   +1 more source

Thermal improvement of existing dwellings [PDF]

, 2005
This report describes the outcome from a study to determine the impact of energy efficiency measures applied to the Scottish housing stock. Assuming conventional property type classifications, the present performance of the housing stock is quantified ...
Clarke, Joseph Andrew, Johnstone, Cameron, Lever, Monica, McElroy, L.B., Prazeres, Luis, Strachan, Paul   +5 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interpretations of Patterns and Actors in the Lapp Fund Documents

Proceedings from the Document Academy, 2014
The Lapp Fund (“Finnefondet” in Norwegian) was an important instrument in the norwegianization policy toward the Sámi and Finnish minorities between 1852 – 1921.
Geir Grenersen
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Papering the Origins: Place-Making, Privacy, and Kinship in Spanish International Adoption

Genealogy, 2019
This article examines place and privacy as two key resources for producing kinship through an analysis of exceptional legal practices in Spain that overdetermine international adoptees’ Spanishness.
Jessaca Leinaweaver
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source