Results 81 to 90 of about 298,412 (99)

High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis. [PDF]

open access: yesCell Rep Med
Huang X   +14 more
europepmc   +1 more source

Creatine ethyl ester: A new substrate for creatine kinase

open access: yesMolecular Biology, 2012
The creatine kinase/phosphocreatine system plays a key role in cell energy buffering and trans port, particularly in cells with high or fluctuating energy requirements, like neurons, i.e.
Silvia Ravera   +2 more
exaly   +2 more sources

Dodecyl creatine ester, a promising treatment to deliver creatine to neurons, achieves pharmacology efficacy in creatine transporter deficiency

open access: yesEuropean Journal of Medicinal Chemistry
International audienceDodecyl creatine ester (DCE) is a creatine prodrug currently developed for brain diseases, including creatine transporter deficiency (CTD), an incurable rare genetic disease.
Aloise Mabondzo   +2 more
exaly   +2 more sources

Di-acetyl creatine ethyl ester, a new creatine derivative for the possible treatment of creatine transporter deficiency

open access: yesNeuroscience Letters, 2018
Creatine is pivotal in energy metabolism of the brain. In primary creatine deficiency syndromes, creatine is missing from the brain. Two of them (AGAT and GAMT deficiency) are due to impaired creatine synthesis, and can be treated by creatine ...
Gianluca Damonte   +2 more
exaly   +2 more sources

Impaired brain glucose metabolism as a biomarker for evaluation of dodecyl creatine ester in creatine transporter deficiency: Insights from patient brain-derived organoids and in vivo [18F]FDG PET imaging in a mouse model

open access: yesNeurobiology of Disease
Creatine transporter deficiency (CTD) is an inborn error of creatine (Cr) metabolism in which Cr is not properly distributed to the brain due to a mutation in the Cr transporter (CrT) SLC6A8 gene.
Lea Broca-Brisson, Anne-Cécile Guyot
exaly   +2 more sources

Non-enzymatic cyclization of creatine ethyl ester to creatinine

open access: yesBiochemical and Biophysical Research Communications, 2009
Creatine ethyl ester was incubated at 37 degrees C in both water and phosphate-buffered saline and the diagnostic methylene resonances in the (1)H NMR spectrum were used to identify the resultant products. It was found that mild aqueous conditions result
Lecher, Carl S., Giese, Matthew W.
exaly   +1 more source

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