Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam+6 more
wiley +1 more source
Longitudinal idiographic assessment of adolescent-dog relationships and adaptive coping for youth with social anxiety: The Teen & Dog Study protocol. [PDF]
Mueller MK+10 more
europepmc +1 more source
AGE AS AFFECTING THE OSMOTIC AND MECHANICAL FRAGILITY OF DOG ERYTHROCYTES TAGGED WITH RADIOACTIVE IRON [PDF]
W. B. Stewart+3 more
openalex +1 more source
Diagnosis of dog allergy: Beware of the dog [PDF]
openaire +4 more sources
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann+6 more
wiley +1 more source
Barriers to rabies control through mass dog vaccination in rural Uganda: Insights from community perspectives and key informant interviews. [PDF]
Akankwatsa D+15 more
europepmc +1 more source
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini+13 more
wiley +1 more source
First Reports of Canine Coccidioidomycosis in the Paso del Norte Region, Mexico-USA: A 10-Case Series. [PDF]
Rodríguez-Alarcón CA+10 more
europepmc +1 more source
Quantitative Assessment of Upper Limb Ataxia Using a Virtual Reality‐Based Evaluation System
ABSTRACT Objective Cerebellar ataxia impairs coordination and balance, reducing quality of life. Conventional clinical scales, including the Scale for the Assessment and Rating of Ataxia (SARA) and the International Cooperative Ataxia Rating Scale (ICARS), are widely used to assess ataxia but are limited by subjectivity and inter‐rater variability ...
Masayuki Sato+5 more
wiley +1 more source