Results 171 to 180 of about 1,709,554 (389)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Nature, 2005
K. Lindblad-Toh, C. Wade, T. Mikkelsen, E. Karlsson, D. Jaffe, Michael Kamal, M. Clamp, Jean L. Chang, E. Kulbokas, M. Zody, E. Mauceli, Xiaohui Xie, M. Breen, R. Wayne, E. Ostrander, C. Ponting, F. Galibert, Douglas R. Smith, P. Dejong, E. Kirkness, P. Alvarez, T. Biagi, W. Brockman, Jonathan Butler, Chee-Wye Chin, A. Cook, James A. Cuff, M. Daly, David DeCaprio, S. Gnerre, M. Grabherr, Manolis Kellis, M. Kleber, C. Bardeleben, L. Goodstadt, A. Heger, C. Hitte, L. Kim, Klaus‐Peter Koepfli, H. Parker, J. Pollinger, S. Searle, N. Sutter, Rachael Thomas, C. Webber, E. Lander   +45 more
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

An assessment of the informativeness of clinical trials in digital mental health

npj Mental Health Research
Clinical trials in digital mental health have grown rapidly, yet little research has examined their informativeness. This study assessed the proportions of recent trials that met indicators of informativeness and explored related factors.
Bridianne O’Dea, Sally Rooke, Eliza-Rose Gordon, Fergus L. Lyons, Bojana Vilus, Neelesh Paravastu, Philip J. Batterham   +6 more
doaj   +1 more source

Metabolic Studies on Cardiac Tissue Obtained by Needle Biopsy in the Intact Unanesthetized Dog [PDF]

, 1953
Gus G. Casten, Julian B. Marsh
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Checklists for improving rigour in qualitative research: a case of the tail wagging the dog?

British medical journal, 2001
R. Barbour
semanticscholar   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Reading Dingo Stories [PDF]

, 2019
A short review of Deborah Bird Rose's Wild Dog Dreaming (2011) University of Virginia ...
Bhat, Harshavardhan, Bhat, Harshavardhan
core  

Some central mechanisms of thirst in the dog. [PDF]

, 1975
D. J. Ramsay, I. A. Reid
openalex   +1 more source