Results 111 to 120 of about 228,704 (299)

Application of a UPLC–MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma

Journal of Pharmaceutical Analysis, 2016
TM-2 known as a potential antitumor drug is a novel semi-synthetic taxane derivative. As drug–protein interactions contribute to insights into pharmacokinetic and pharmacodynamic properties, we elucidated the binding of TM-2 to plasma protein.
Hui Liu, Pan-Pan Wu, Ming-Jing Yang, Lei Men, Hong-Li Lin, Yun-Li Zhao, Xing Tang, Zhi-Guo Yu   +7 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Iconic and non-iconic stages in number development : the role of language [PDF]

, 2010
Is language the key to number? This article argues that the human language faculty provides the cognitive equipment that enables humans to develop a systematic number concept.
Wiese, Heike
core  

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Population Demographics of Owned Dogs in Greater Bangkok and Implications for Free-Roaming Dog Population Management

Animals
Greater Bangkok, Thailand, has large numbers of both owned and free-roaming dogs, two populations that intersect and overlap in complex and nuanced ways. A more robust understanding of owned dog populations is, therefore, important not only in supporting
Elly Hiby, Tuntikorn Rungpatana, Alicja Izydorczyk, Valerie Benka, Craig Rooney   +4 more
doaj   +1 more source

Chicken Consumption and Use of Acid-Suppressing Medications as Risk Factors for Campylobacter Enteritis, England

Emerging Infectious Diseases, 2009
In a case–control study of Campylobacter spp. risk factors in England during 2005–2006, we identified recent consumption of commercially prepared chicken as an important risk factor.
Clarence C. Tam, Craig D. Higgins, Keith R. Neal, Laura C. Rodrigues, Sally E. Millership, Sarah J. O’Brien   +5 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Ex Vivo Fluorescence Molecular Tomography of the Spine

International Journal of Biomedical Imaging, 2012
We investigated the potential of fluorescence molecular tomography to image ex vivo samples collected from a large animal model, in this case, a dog spine.
Monish Pimpalkhare, Jin Chen, Vivek Venugopal, Xavier Intes   +3 more
doaj   +1 more source

Acquisition in the course of conversation [PDF]

, 1999
published or submitted for publicationis peer ...
Clark, Eve V.
core  

Predicting and Explaining Human Semantic Search in a Cognitive Model

, 2017
Recent work has attempted to characterize the structure of semantic memory and the search algorithms which, together, best approximate human patterns of search revealed in a semantic fluency task.
Miscevic, Filip, Nematzadeh, Aida, Stevenson, Suzanne   +2 more
core   +1 more source