Results 131 to 140 of about 1,211,793 (274)

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

Advanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso, Sara Carpi, Laura Colagiorgio, Miriam De Sarlo, Mariacristina Gagliardi, Marco Cecchini   +5 more
wiley   +1 more source

A Novel Approach on Rapid Alloy Development of Tool Steels for Laser Powder Bed Fusion by In Situ Alloying

Advanced Engineering Materials, EarlyView.
A novel approach for alloy development in laser powder bed fusion is introduced. Instead of producing massive samples of one composition at a time, prepressed powder bed samples produced from powder mixtures are processed. Guidelines for the selection of precursor powders are developed.
Felix Großwendt, Anna Strauch, Jonathan Lentz, Arne Röttger, Rainer Fechte‐Heinen, Sebastian Weber, Werner Theisen   +6 more
wiley   +1 more source

Comparative subcutaneous and submuscular implantation of an electroencephalography device for long term electroencephalographic monitoring in dogs

Frontiers in Veterinary Science
BackgroundImplantable electroencephalography (EEG) recording devices have been used for ultra-long-term epilepsy monitoring both in clinical and home settings in people.
Casey B. Rogers, Sebastian Meller, Nina Meyerhoff, Holger A. Volk, Holger A. Volk   +4 more
doaj   +1 more source

Enhancing the Age‐Hardening Response of Laser Powder‐Bed Fusion WE43 Alloy through Microstructural Control

Advanced Engineering Materials, EarlyView.
Laser powder‐bed fusion (L‐PBF) can produce dense WE43 magnesium alloy parts, but their mechanical properties are limited by a nonhomogeneous microstructure. This study investigates the effects of varying direct aging (T5) and artificial age‐hardening (T6) conditions on microstructure and strength. Optimized T6 treatment significantly improves strength
Prathviraj Upadhyaya, Sinéad M. Uí Mhurchadha, Oliver J. McCarthy, Tríona Kennedy, Mert Celikin, Ramesh Raghavendra   +5 more
wiley   +1 more source

Statistical Distributions of Morphologically Classified Defects in Metal Additive Manufacturing with Implications for Fatigue Life Prediction

Advanced Engineering Materials, EarlyView.
Morphological features of three defect types in metal additive manufacturing (AM)—lack of fusion, keyhole, and gas‐entrapped pores—are statistically characterized using best‐fit distributions evaluated via coefficient‐of‐determination, Kolmogorov–Smirnov test, and quantile–quantile plots.
Ahmad Serjouei, Golnaz Shahtahmassebi
wiley   +1 more source

Laser Additive Manufacturing of Oxide‐Dispersion‐Strengthened Steels: A Simulation‐Based Comparison Between Powder Bed Fusion and Direct Energy Deposition

Advanced Engineering Materials, EarlyView.
Controlling the size and distribution of dispersoids is essential for optimizing the performance of oxide‐dispersion‐strengthened steels. This study focuses on nanoparticle dispersion and agglomeration during laser additive manufacturing of Fe20Cr alloy reinforced with ZrO 2 nanoparticles. Utilizing multiphysics phase‐field simulations and nanoparticle
Somnath Bharech, Yangyiwei Yang, Timileyin David Oyedeji, Prasanth Bondi, Mareen Goßling, Bilal Gökce, Bai‐Xiang Xu   +6 more
wiley   +1 more source

Influence of Temperature on Scratch and Wear Properties of Technical Thermoplastics: Implications for Material Selection

Advanced Engineering Materials, EarlyView.
The share of technical thermoplastics is expected to grow further in the e‐mobility segment. In this study, a detailed temperature‐based tribological characterization of technical thermoplastics is performed. The tribological properties are discussed in terms of the dynamic mechanical properties of polymers at different ambient temperatures. A proof of
Harsha Raghuram, Thomas Koch, Vasiliki-Maria Archodoulaki   +2 more
wiley   +1 more source

Development of Aluminum Scandium Alloys for Hydrogen Storage Valves

Advanced Engineering Materials, EarlyView.
Different aluminum alloy series and various aluminum‐scandium alloys with differing Sc and Zr levels are evaluated for use in hydrogen storage valve production. The alloys undergo hardness testing, optical microscopy, and tensile strength analysis, with hardening behavior studied under varying conditions.
Francisco García‐Moreno, Tillmann Robert Neu, Markus Eberl, Paul Hans Kamm, Hans‐Wolfgang Seeliger   +4 more
wiley   +1 more source

Residual Stress States in Microstructurally Graded PBF–LB/M Austenitic Steel Components

Advanced Engineering Materials, EarlyView.
This study examines microstructurally graded 316L rectangular tube profiles fabricated via PBF–LB/M using a dual‐laser system. A 1 kW top‐hat and a 400 W Gaussian laser create distinct grain sizes and crystallographic texture. Mechanical properties are linked to microstructural evolution driven by processing conditions.
Nico Möller, Florian Loebich, Thomas Wegener, Julia Richter, Jens Gibmeier, Thomas Niendorf   +5 more
wiley   +1 more source

Optimized Strategy for Fabricating High‐Aspect‐Ratio Periodic Structures Over Large Areas Using ps‐Direct Laser Interference Patterning

Advanced Engineering Materials, EarlyView.
Picosecond direct laser interference patterning (DLIP) enables precise microstructure fabrication on stainless steel. Using a multiscan approach, high‐aspect‐ratio patterns are achieved. Fluence influences structure growth and homogeneity, with smaller periods yielding better uniformity.
Fabian Ränke, Marcelo Sallese, Marcos Soldera, Ignacio Tabares, Flavio Soldera, Andrés Fabián Lasagni   +5 more
wiley   +1 more source