Results 81 to 90 of about 228,704 (299)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Rapid learning of an abstract language-specific category: Polish children's acquisition of the instrumental construction [PDF]

, 2008
Rapid acquisition of linguistic categories or constructions is sometimes regarded as evidence of innate knowledge. In this paper, we examine Polish children's early understanding of an idiosyncratic, language-specific construction involving the ...
Bańko, Chomsky, Chomsky, Dąbrowska, Dąbrowska, EWA DĄBROWSKA, Hyams, Lakoff, Langacker, Langacker, Lindner, MICHAEL TOMASELLO, Slobin, Smoczyńska, Stolz, Tomasello   +15 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Parameter identification for coupled elasto-plasto-damage model for overheated concrete

MATEC Web of Conferences, 2017
The methodology of experimental acquisition and subsequent processing of data for identification of nonlinear elasto-plasto-damage concrete model parameters are considered. Typical measurement equipment and data acquisition process are described.
Benin Andrey, Semenov Sergey, Semenov Artem, Bogdanova Galina   +3 more
doaj   +1 more source

Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog

Medical Mycology Case Reports, 2016
Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene ...
Sergio Álvarez-Pérez, Marta E. García, María Teresa Cutuli, María Luisa Fermín, María Ángeles Daza, Teresa Peláez, José L. Blanco   +6 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Suggesting Cooking Recipes Through Simulation and Bayesian Optimization

, 2018
Cooking typically involves a plethora of decisions about ingredients and tools that need to be chosen in order to write a good cooking recipe. Cooking can be modelled in an optimization framework, as it involves a search space of ingredients, kitchen ...
B Shahriari, CE Rasmussen, K Doman, L Cornejo-Bueno   +3 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder. [PDF]

, 2006
The DSM-III, DSM-IV, DSM-IV-TR and ICD-10 have judiciously minimized discussion of etiologies to distance clinical psychiatry from Freudian psychoanalysis.
Bracha, Dr. H. Stefan
core   +1 more source

The Role of Striatum in the Acquisition of Instrumental Defensive Reactions in Dogs

, 1980
The model of instrumental defensive reflexes, connected with the maintenance of a certain posture, was used in a chronic experiment on dogs. The motor components of "coordinating" and "cognitive" programs of defensive reflexes were analysed before and after stimulation of the head of the caudate nucleus (CNH). Predominantly inhibitory influences of the
K B, Shapovalova, S I, Bazhenova
openaire   +2 more sources