Results 81 to 90 of about 229,011 (298)

Lexical organization in deaf children who use British Sign Language: Evidence from a semantic fluency task [PDF]

, 2013
We adapted the semantic fluency task into British Sign Language (BSL). In Study 1, we present data from twenty-two deaf signers aged four to fifteen. We show that the same ‘cognitive signatures’ that characterize this task in spoken languages are also ...
Allen, Anderson, Blamey, Buriel, Cain, CHLOE R. MARSHALL, Conrad, Edwards, Elliot, GARY MORGAN, Herman, Herman, KATHERINE ROWLEY, KATHRYN MASON, Leonard, Lillo-Martin, Marschark, ROSALIND HERMAN   +17 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Determination of left ventricular mass in dogs with rapid-acquisition cardiac computed tomographic scanning. [PDF]

Circulation, 1985
The development of left ventricular hypertrophy in patients with heart disease often has far-reaching clinical implications with respect to overall morbidity and mortality. Approaches used to assess left ventricular mass include electrocardiography, echocardiography, contrast ventriculography, single photon-emission tomography, and conventional ...
A J, Feiring, J A, Rumberger, S J, Reiter, D J, Skorton, S M, Collins, M J, Lipton, C B, Higgins, S, Ell, M L, Marcus   +8 more
openaire   +2 more sources

Implicit learning of recursive context-free grammars [PDF]

, 2012
Context-free grammars are fundamental for the description of linguistic syntax. However, most artificial grammar learning experiments have explored learning of simpler finite-state grammars, while studies exploring context-free grammars have not ...
Johan J. Bolhuis, Martin Rohrmeier, Qiufang Fu, Zoltan Dienes   +3 more
core   +3 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Parameter identification for coupled elasto-plasto-damage model for overheated concrete

MATEC Web of Conferences, 2017
The methodology of experimental acquisition and subsequent processing of data for identification of nonlinear elasto-plasto-damage concrete model parameters are considered. Typical measurement equipment and data acquisition process are described.
Benin Andrey, Semenov Sergey, Semenov Artem, Bogdanova Galina   +3 more
doaj   +1 more source

Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog

Medical Mycology Case Reports, 2016
Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene ...
Sergio Álvarez-Pérez, Marta E. García, María Teresa Cutuli, María Luisa Fermín, María Ángeles Daza, Teresa Peláez, José L. Blanco   +6 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Rapid learning of an abstract language-specific category: Polish children's acquisition of the instrumental construction [PDF]

, 2008
Rapid acquisition of linguistic categories or constructions is sometimes regarded as evidence of innate knowledge. In this paper, we examine Polish children's early understanding of an idiosyncratic, language-specific construction involving the ...
Bańko, Chomsky, Chomsky, Dąbrowska, Dąbrowska, EWA DĄBROWSKA, Hyams, Lakoff, Langacker, Langacker, Lindner, MICHAEL TOMASELLO, Slobin, Smoczyńska, Stolz, Tomasello   +15 more
core   +1 more source