Results 81 to 90 of about 1,252,496 (259)

Caregiver anxiety and reported dog anxiety in the context of history and acquisition factors

Human-Animal Interactions
Background: Prior research in human-animal interaction has documented associations between human anxiety and anxiety-related behaviors in pet dogs. However, this literature has rarely accounted for dogs’ prior adverse experiences or related contextual ...
Lexis H. Ly, Jada K. Ford, Kate J. Miller, Sarah R.B. King, Amelia Malone, Shelby E. McDonald   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Factors Associated with Puppy Training Class Attendance

Animals
Attending puppy training classes may help to improve the human–dog relationship and the overall behaviour and trainability of the dog, yet class attendance and the structure and content of classes are not well known. This study aimed to describe the size
Emma L. Buckland, Rachel H. Kinsman, Jessie Fitts, Rachel Casey, Séverine Tasker, Jane K. Murray   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Collaboration Practices: An Analysis Within an Army Acquisition Program Office [PDF]

, 2014
Annual Acquisition Research SymposiumNaval Postgraduate School Naval Postgraduate School Acquisition Research ...
Blanton, Joseph R., Naval Postgraduate School Acquisition Research Program   +1 more
core   +2 more sources

Volume II Acquisition Research Creating Synergy for Informed Change, Wednesday 18th Annual Acquisition Research Proceedings [PDF]

, 2021
Approved for public release; distribution is unlimited.Approved for public release; distribution is unlimited.Prepared for the Naval Postgraduate School, Monterey, CA 93943.Naval Postgraduate ...
Acquisition Research Program
core   +1 more source

Lasting lockdown love? Problem behaviour and pandemic and non-pandemic related risk factors influencing the owner-dog relationship in a UK cohort of dogs reaching early adulthood.

PLoS ONE
The owner-dog relationship is a critical component of sustained dog ownership. Increased understanding of risk factors for weak owner-dog relationships can identify owner-dog dyads at higher risk of poor welfare outcomes, including dog relinquishment and
Bree L Merritt, Dan G O'Neill, Claire L Brand, Zoe Belshaw, Fiona C Dale, Camilla L Pegram, Rowena M A Packer   +6 more
doaj   +1 more source

Parameter identification for coupled elasto-plasto-damage model for overheated concrete

MATEC Web of Conferences, 2017
The methodology of experimental acquisition and subsequent processing of data for identification of nonlinear elasto-plasto-damage concrete model parameters are considered. Typical measurement equipment and data acquisition process are described.
Benin Andrey, Semenov Sergey, Semenov Artem, Bogdanova Galina   +3 more
doaj   +1 more source

Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog

Medical Mycology Case Reports, 2016
Multi-azole resistance acquisition by Candida tropicalis after prolonged antifungal therapy in a dog with urinary candidiasis is reported. Pre- and post-azole treatment isolates were clonally related and had identical silent mutations in the ERG11 gene ...
Sergio Álvarez-Pérez, Marta E. García, María Teresa Cutuli, María Luisa Fermín, María Ángeles Daza, Teresa Peláez, José L. Blanco   +6 more
doaj   +1 more source