Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits
Advanced Science, EarlyView.A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu +5 more
wiley +1 more source
Recurrent secondary milia after full-thickness skin graft using retroauricular donor skin for dog-bite defect: a case report. [PDF]
Arch Craniofac SurgKim MW, Keum CR, Seo KS, Seo JY.
europepmc +1 more source
Advanced Science, EarlyView.A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu +8 more
wiley +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
State-wise geospatial analysis of dog bite burden in India from 2018 to 2023. [PDF]
Porto Biomed JJanekunte DB +2 more
europepmc +1 more source
A review of human dog-bite injuries in Kitui South subcounty, Kenya (2017-2021). [PDF]
Vet Rec Open, 2023 Kung U P, Brodbelt D.
europepmc +1 more source
Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity
Advanced Science, EarlyView.This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao +11 more
wiley +1 more source
A rare case of repeat severe facial dog bite injuries requiring two free flap reconstructions. [PDF]
JPRAS OpenClough R, Al-Azzawi M, Iyer S.
europepmc +1 more source
Antimicrobials in dog-to-dog bite wounds: A retrospective study of 1526 dog bite events (1999-2019). [PDF]
J Vet Intern Med, 2022 Kalnins NJ +6 more
europepmc +1 more source
Deep Volumetric Super‐Resolution Imaging in Thick Biological Specimens With Sparse Scanning SIM
Advanced Science, EarlyView.Sparse scanning structured illumination microscopy (SS‐SIM) extends the axial depth in super‐resolution fluorescence imaging by combining rapid laser scanning, pixel‐addressed intensity modulation, and sCMOS camera detection. SS‐SIM yields 1.6× lateral and 1.7× axial resolution gains over wide‐field microscopy and enables imaging through 300–600 µm ...
Sha An +8 more
wiley +1 more source