Results 81 to 90 of about 9,684,425 (379)

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs

Journal of Veterinary Internal Medicine
Background Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking. Objectives Identify clinicopathologic features that differentiate pITP from secondary ITP (sITP) and markers related ...
Marjory B. Brooks, Robert Goggs, Amelia H. Frye, Jessica Armato, Marnin Forman, Julia Hertl, Michael Koch, John P. Loftus, John Lucy, Brandi Mattison, Julia Merriam, Sarah Shropshire, Laura Van Vertloo, Austin Viall, Dana N. LeVine   +14 more
doaj   +1 more source

Sensitive, non-invasive detection of chronic wasting disease in wild and captive white-tailed deer using fecal volatile profiling

mSphere
Chronic wasting disease (CWD) is a universally fatal, transmissible prion disease affecting cervids. Primarily found among deer populations in North America, the disease has spread across the continent and made forays into Europe and Asia as well ...
Amalia Z. Berna, Tzvi Y. Pollock, Yang Liu, Michelle Gibison, Amritha Mallikarjun, Joey Logan, Cynthia M. Otto, Audrey R. Odom John   +7 more
doaj   +1 more source

Survey of dog owners’ and veterinarians’ attitudes regarding the selection of flea and tick prevention products in Thailand [PDF]

Veterinary World
Background and Aim: Tick and flea infestations in dogs are significant concerns for both dog owners and veterinarians in Thailand. The country’s climate provides an optimal environment for the proliferation of ticks and fleas, thereby increasing the risk
Pornlapas Panchim, Pinrumpai Saengpradub, Sajitha Rakkijpradit, Apichaya Watananontchai, Piyarat Chansiripornchai, Kris Angkanaporn   +5 more
doaj   +1 more source

Epidemics and pandemics : Covid-19 and the ‘‘drop of honey effect’’ [PDF]

, 2020
Purpose: The aim of this paper is the use of the “drop of honey effect” to explain the spread of Covid-19. Approach/Methodology/Design: After Covid-19 appearance in Wuhan, in the Chinese province of Hubei, by December, 2019, it spread all over the world.
Filipe, Jose Antonio
core   +2 more sources

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Denz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

Certified service dogs - A cost-effectiveness analysis appraisal.

PLoS ONE, 2019
IntroductionIndividuals with functional impairments or chronic diseases are often in need of assistance in their daily lives. For these individuals it is essential to find novel, cost-effective solutions to meet their needs.
Martina Lundqvist, Jenny Alwin, Lars-Åke Levin   +2 more
doaj   +1 more source

D159 and S167 are protective residues in the prion protein from dog and horse, two prion-resistant animals

Neurobiology of Disease, 2018
Prion diseases are fatal neurodegenerative diseases caused by misfolding of the prion protein (PrP). These conditions affect humans and animals, including endemic forms in sheep and deer.
Jonatan Sanchez-Garcia, Pedro Fernandez-Funez   +1 more
doaj   +1 more source

Mission to Indonesia to participate to the 1st Indonesia- France Seminar in Medicine & Public Health and investigate potential collaborations on animal health : 2nd - 9th of November 2012 [PDF]

, 2012
Emerging and zoonotic infectious diseases are a major issue in Indonesia. The objective of this mission, funded by the Institut Français d'Indonésie (IFI), was to identify potential subjects of collaboration between CIRAD, Pasteur Institute, and ...
Bourhy, Hervé, Gaidet, Nicolas, Molia, Sophie   +2 more
core