Results 81 to 90 of about 9,464,894 (393)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Effects of pregnancy on neuromyelitis optica spectrum disorder and predictors of related attacks

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1918-1925, December 2022., 2022
Abstract Objective Our study aimed to investigate the influence of pregnancy on the course of neuromyelitis optica spectrum disorders (NMOSD) and to explore the independent predictors of pregnancy‐related attacks. Methods We performed a retrospective study of patients with NMOSD based on the Wingerchuk 2006 or the revised Wingerchuk 2015 criteria ...
Qin Du, Ziyan Shi, Hongxi Chen, Ying Zhang, Yuhan Qiu, Yanlin Lang, Lingyao Kong, Hongyu Zhou   +7 more
wiley   +1 more source

Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds [PDF]

, 2017
Background Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features.
Evans, K M, Lewis, T W, Llewellyn-Zaidi, A M, O'Neill, D G, Wiles, B M   +4 more
core   +2 more sources

Epidemiologia de problemas comportamentais em cães no Brasil: inquérito entre médicos veterinários de pequenos animais Epidemiology of dogs behavioral problems in Brazil: a survey between small animals veterinary practitioners

Ciência Rural, 2010
Problemas de comportamento afetam diretamente a qualidade de vida dos animais e das pessoas que com eles convivem. Em alguns países, os problemas de comportamento são as principais causas de abandono e eutanásia de animais de companhia. O presente estudo
Guilherme Marques Soares, Letícia Mattos de Souza-Dantas, José Mário D’Almeida, Rita Leal Paixão   +3 more
doaj  

A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs

Journal of Veterinary Internal Medicine
Background Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking. Objectives Identify clinicopathologic features that differentiate pITP from secondary ITP (sITP) and markers related ...
Marjory B. Brooks, Robert Goggs, Amelia H. Frye, Jessica Armato, Marnin Forman, Julia Hertl, Michael Koch, John P. Loftus, John Lucy, Brandi Mattison, Julia Merriam, Sarah Shropshire, Laura Van Vertloo, Austin Viall, Dana N. LeVine   +14 more
doaj   +1 more source

A Large Scale Spatio-temporal Binomial Regression Model for Estimating Seroprevalence Trends [PDF]

, 2018
This paper develops a large-scale Bayesian spatio-temporal binomial regression model for the purpose of investigating regional trends in antibody prevalence to Borrelia burgdorferi, the causative agent of Lyme disease. The proposed model uses Gaussian predictive processes to estimate the spatially varying trends and a conditional autoregressive model ...
arxiv   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Early‐onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late‐onset

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1962-1973, December 2022., 2022
Abstract Objectives Early‐ and late‐onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain‐specific cognitive function in a well characterized cohort of patients with a biomarker‐based diagnosis.
Adrià Tort‐Merino, Neus Falgàs, Isabel E. Allen, Mircea Balasa, Jaume Olives, José Contador, Magdalena Castellví, Jordi Juncà‐Parella, Núria Guillén, Sergi Borrego‐Écija, Bea Bosch, Guadalupe Fernández‐Villullas, Oscar Ramos‐Campoy, Anna Antonell, Lorena Rami, Raquel Sánchez‐Valle, Albert Lladó   +16 more
wiley   +1 more source

Elucidating the phylodynamics of endemic rabies virus in eastern Africa using whole-genome sequencing [PDF]

, 2015
Many of the pathogens perceived to pose the greatest risk to humans are viral zoonoses, responsible for a range of emerging and endemic infectious diseases.
Biek, Roman, Brunker, Kirstyn, Cleaveland, Sarah, Fooks, AR, Hampson, Katie, Horton, Daniel L, Kazwala, Rudovick, Lembo, Tiziana, Marston, Denise A, Mtema, Zacharia J, Ngeleja, Chanasa, Sambo, Maganga, Sikana, Lwitiko, Wilkie, Gavin   +13 more
core   +1 more source

Dog assisted education in children with rheumatic diseases and adolescents with chronic pain in Germany

GMS Journal for Medical Education, 2023
Objectives: Animal assisted intervention is an increasingly accepted tool to improve human well-being. The present study was performed to assess whether dog assisted education has a positive effect on children suffering from rheumatic disorders with pain
Kiesewetter, Jan, Herbach, Nadja, Landes, Iris, Mayer, Julia, Elgner, Verena, Orle, Karin, Grunow, Alexandra, Langkau, Rovena, Gratzer, Christine, Jansson, Annette F.   +9 more
doaj   +1 more source