Results 231 to 240 of about 163,909 (281)

Single‐Cell RNA Sequencing of Human Lung Tissues Reveals Metallothionein‐Positive T Cells as a Novel Potential Marker of Susceptibility to Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
Using single‐cell RNA sequencing of lung samples and flow cytometry of peripheral blood, we identified a novel T cell subset with high metallothionein (MT) expression. These MT‐high T cells suppress CD8+ T cell cytotoxicity and are progressively depleted from healthy controls to chronic obstructive pulmonary disease (COPD) patients, positioning them as
Zengqing Liu, Xiaoxia Ren, Mi Mu, Huanyu Long, Jialu Lv, Zhihong Feng, Jie Liu, Jiajia Wang, Hui Deng, Fanyu Shi, Muzhi Zhang, Ruoyang Zhang, Yang Liu, Mengyu Xu, Yang Fan, Zengtao Wang, Zhe Lv, Yan Chen, Chris J. Corrigan, Ying Sun, Yahong Chen, Chen Chen, Ye Cui, Wei Wang   +23 more
wiley   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

A Supramolecular Ferroelectric With Two Sublattices and Polarization Dependent Conductivity

Advanced Science, EarlyView.
Ferroelectric behavior in a supramolecular material with two, independently switchable, sublattices is demonstrated. The sublattices can be associated with the two dipolar groups in the compound. Moreover, the polarization is found to couple to the charge transport in the material, giving rise to a switchable, directional conductivity.
H. Mager, M. Litterst, Sophia Klubertz, Shyamkumar V. Haridas, Oleksandr Shyshov, M. von Delius, M. Kemerink   +6 more
wiley   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Factors influencing pet dog ownership in Bengaluru City

International Journal of Veterinary Sciences and Animal Husbandry
Sooguresh Jaka, Vivek M Patil, Mahadevappa D Gouri, PT Ramesh, Madhusudhan HS, Harish Shenoy   +5 more
openaire   +1 more source

The effects of dog ownership on social capital

openaire   +1 more source

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Relational Dimensions of Dog Ownership

Psychological Reports, 1996
The objective was to identify the perceptual dimensions which underlie the relationship between a dog and its owner. Perceptions of 248 dog owners concerning their dogs' skills and activities were assessed. A principal factor analysis yielded dimensions of freedom and privileges of a family member, advanced skills, and basic skills.
John R. Walton, Diane M. McConocha
openaire   +1 more source

Irresponsible dog ownership

In Practice, 2011
Your neighbours buy two beagles and house them in a purpose‐built compound. During the week, both occupants leave for work early and return in the evening, and they are often away at weekends. A paid dog walker exercises the dogs for about 50 minutes a day during the week and spends a further 10 minutes feeding them and cleaning up.
openaire   +1 more source

Encouraging responsible dog ownership in Africa

Veterinary Record, 2019
According to the American Veterinary Medical Association, responsible pet ownership entails 14 key responsibilities, one of which is recognising that owning a pet requires the investment of both time and money.1 Many studies have recognised that responsible dog ownership is key in the fight against rabies.2-5 To successfully eliminate rabies, it is ...
openaire   +2 more sources

Dog Ownership and Dog Walking

Journal of Cardiovascular Nursing, 2018
Background: Dog ownership has been associated with increased physical activity in the general adult population. Objective: The objective of this study was to examine dog ownership and dog walking and their relationship with home-based and phase II cardiac rehabilitation exercise ...
Susan L, Dunn, Michael, Sit, Holli A, DeVon, Devynn, Makidon, Nathan L, Tintle   +4 more
openaire   +2 more sources