Results 161 to 170 of about 26,459,420 (340)
Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro +28 morewiley +1 more sourceEditorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652
, 2016 D. Klionsky, K. Abdelmohsen, A. Abe, M. Abedin, H. Abeliovich, A. Arozena, H. Adachi, C. Adams, P. Adams, K. Adeli, P. Adhihetty, S. Adler, G. Agam, R. Agarwal, M. Aghi, M. Agnello, P. Agostinis, Pv Aguilar, J. Ghiso, E. Airoldi, S. A. Ali, T. Akematsu, E. Akporiaye, M. A. Rubeai, G. Albaiceta, C. Albanese, D. Albani, M. Albert, J. Aldudo, H. Algül, M. Alirezaei, I. Alloza, A. Almasan, M. A. Beceril, Es Alnemri, C. Alonso, N. Bonnet, D. Altieri, Silvia Alvarez, L. A. Erviti, Sandro Alves, G. Amadoro, A. Amano, C. Amantini, S. Ambrosio, I. Amelio, A. Amer, M. Amessou, A. Amon, Zhenyi An, F. Anania, Susan M. K. Andersen, U. Andley, C. Andreadi, N. Abadie, A. Anel, D. Ann, S. Dukie, M. Antonioli, H. Aoki, N. Apostolova, S. Aquila, K. Aquilano, K. Araki, E. Arama, A. Aranda, Jun Araya, A. Arcaro, E. Arias, H. Arimoto, Ar Ariosa, J. Armstrong, T. Arnould, I. Arsov, K. Asanuma, Askanas, E. Asselin, Ryuichiro Atarashi, S. Atherton, J. Atkin, Ld Attardi, P. Auberger, G. Auburger, L. Aurelian, R. Autelli, L. Avagliano, M. Avantaggiati, L. Avrahami, S. Awale, N. Azad, T. Bachetti, J. Backer, D. Bae, J. Bae, On Bae, S. Bae, Eh Baehrecke, S. Baek, S. Baghdiguian, A. B. Zadworna, Hua Bai, J. Bai, X. Bai, Y. Bailly, Kn Balaji, W. Balduini, A. Ballabio, R. Balzan, R. Banerjee, G. Bánhegyi, Haijun Bao, B. Barbeau, Barrachina, E. Barreiro, B. Bartel, Alberto Bartolomé, D. Bassham, M. Bassi, R. Bast, A. Basu, M. Batista, H. Batoko, M. Battino, K. Bauckman, Bl Baumgarner, K. Bayer, R. Beale, J. Beaulieu, G. Beck, Christoph Becker, J. Beckham, P. Bédard, P. Bednarski, T. Begley, C. Behl, C. Behrends, G. Behrens, K. Behrns, Eloy Bejarano, Amine Belaid, F. Belleudi, G. Bénard, G. Berchem, D. Bergamaschi, M. Bergami, B. Berkhout, L. Berliocchi, Amélie Bernard, Monique Bernard, F. Bernassola, A. Bertolotti, A. Bess, Sébastien Besteiro, S. Bettuzzi, Savita Bhalla, S. Bhattacharyya, S. Bhutia, Caroline A Biagosch, M. Bianchi, M. Piechaczyk, Billes, C. Bincoletto, Baris Bingol, S. Bird, M. Bitoun, I. Bjedov, C. Blackstone, L. Blanc, G. Blanco, H. Blomhoff, E. B. Romero, Stefan Böckler, M. Boes, K. Battaglia, L. Boise, A. Bolino, Andrea Boman, P. Bonaldo, M. Bordi, J. Bosch, Lm Botana, J. Botti, G. Bou, M. Bouché, M. Bouchecareilh, Mj Boucher, M. Boulton, S. Bouret, P. Boya, M. Guittaut, P. Bozhkov, N. Brady, Vm Braga, C. Brancolini, G. Braus, Bravo San Pedro Jm, Laura A. Brennan, E. Bresnick, P. Brest, D. Bridges, M. Bringer, M. Brini, G. Brito, B. Brodin, P. Brookes, Ej Brown, Karen P. Brown, H. Broxmeyer, A. Bruhat, P. Brum, Jh Brumell, N. Pierri, B. Rj, S. Buch, A. Buchan, H. Budak, D. Bulavin, S. Bultman, G. Bultynck, Bumbasirevic, Y. Burelle, R. Burke, M. Burmeister, P. Bütikofer, L. Caberlotto, K. Cadwell, M. Cahova, D. Cai, J. Cai, Qian Cai, S. Calatayud, N. Camougrand, M. Campanella, G. Campbell, M. Campbell, S. Campello, R. Candau, I. Caniggia, L. Cantoni, Lizhi Cao, A. Caplan, M. Caraglia, C. Cardinali, Sm Cardoso, J. Carew, L. Carleton, Cr Carlin, S. Carloni, Carlsson, D. C. Gutierrez, L. Carneiro, O. Carnevali, Serena Carra, A. Carrier, Bernadette Carroll, Caty Casas, J. Casas, G. Cassinelli, P. Castets, S. C. Obregon, G. Cavallini, I. Ceccherini, F. Cecconi, A. Cederbaum, Ceña, S. Cenci, C. Cerella, D. Cervia, S. Cetrullo, Hassan Chaachouay, H. Chae, A. Chagin, Cy Chai, Gopal Chakrabarti, Georgios Chamilos, Ey Chan, M. Chan, D. Chandra, P. Chandra, Cp Chang, R. Chang, Ty Chang, J. Chatham, S. Chatterjee, S. Chauhan, Y. Che, M. Cheetham, Rajkumar Cheluvappa, Cj Chen, Guang-Chao Chen, Gc Chen, Hongzhuan Chen, Jw Chen, J. Chen, Mingzhou Chen, Peiwen Chen, Quan Chen, Sd Chen, S. Chen, Ss Chen, Wen Qiang Chen, Wj Chen, Wq Chen, Xiangmei Chen, Y. Chen, Yg Chen, Yue‐Qin Chen, Yj Chen, Yq Chen, Zhong Chen, Alan Cheng, C.-h. Cheng, Hua Cheng, H. Cheong, S. Cherry, J. Chesney, C. Cheung, É. Chevet, H. Chi, Sg Chi, Fulvio Chiacchiera, Hl Chiang, R. Chiarelli, M. Chiariello, M. Chieppa, Ls Chin, M. Chiong, G. Chiu, Dh Cho, S-G Cho, W.Y. Cho, Yy Cho, Ys Cho, A. Choi, E-Ryung Choi, Ek Choi, Jayoung Choi, Meena Choi, Si-On Choi, T. Chou, S. Chouaib, D. Choubey, Choubey, Kc Chow, K. Chowdhury, C. Chu, T. Chuang, T. Chun, Hyewon Chung, Taijoon Chung, Y-J Chung, Y. Chwae, Cianfanelli, R. Ciarcia, Ia Ciechomska, Ciriolo, M. Cirone, S. Claerhout, Mj Clague, J. Clària, P. Clarke, R. Clarke, E. Clementi, C. Cleyrat, M. Cnop, E. Coccia, T. Cocco, P. Codogno, J. Coers, E. Cohen, D. Colecchia, L. Coletto, N. Coll, E. Guyon, S. Comincini, M. Condello, K. Cook, G. Coombs, C. Cooper, J. Cooper, I. Coppens, M. Corasaniti, Marco Corazzari, R. Corbalán, E. C. Termeau, Cordero, C. Ramos, O. Corti, A. Cossarizza, P. Costelli, S. Costes, S. Cotman, A. Montes, S. Cottet, E. Couve, L. Covey, L. Cowart, J. Cox, F. Coxon, C. Coyne, Cragg, R. Craven, T. Crepaldi, J. Crespo, A. Criollo, Crippa, M. Jason de la Cruz, Am Cuervo, J. Cuezva, T. Cui, P. Cutillas, M. Czaja, Czyzyk Krzeska Mf, Rk Dagda, U. Dahmen, C. Dai, W. Dai, Yun Dai, Kn Dalby, L. Valle, G. Dalmasso, M. D’Amelio, M. Damme, A. Michaud, C. Dargemont, D. Vm, S. Dasarathy, B. Dasgupta, S. Dash, C. Dass, H. Davey, L. Davids, D. Dávila, R. Davis, T. Dawson, V. Dawson, P. Daza, J. Belleroche, P. Figueiredo, D. Rc, J. Fuente, L. Martino, A. D. Matteis, Deen Gr, A. Milito, M. D. Santi, W. Souza, Despina A. Tata, D. Zio, Jayanta Debnath, Reinhard Dechant, Jp Decuypere, S. Deegan, B. Dehay, B. Bello, Del Re Dp, R. D. Mourroux, L. Delbridge, L. Deldicque, E. D. Axford, Y. Deng, J. Dengjel, M. Denizot, P. Dent, C. Der, Deretic, Benoît Derrien, E. Deutsch, Tp Devarenne, R. Devenish, S. Bartolomeo, N. Daniele, F. Domenico, A. Nardo, S. D. Paola, A. Pietro, L. Renzo, A. Diantonio, G. D. Araya, I. Laviada, Diaz Meco Mt, J. Nido, C. Dickey, R. Dickson, M. Diederich, P. Digard, I. Dikič, D. Sp, C. Ding, W. Ding, Zufeng Ding, L. Dini, J. Distler, A. Diwan, M. Mergny, K. Dmytruk, R. Dobson, Doetsch, K. Dokladny, S. Dokudovskaya +499 moresemanticscholar +1 more sourceMulti‐Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects
Advanced Science, EarlyView.The study proposes graph convolution network with sparse pooling to learn the hierarchical features of brain graph for MDD classification. Experiment is done on multi‐site fMRI samples (3335 subjects, the largest functional dataset of MDD to date) and transfer learning is applied, achieving an average accuracy of 70.14%.Jianpo Su, Jian Qin, Hui Shen, Ling‐Li Zeng, Baojuan Li, Jin Liu, Xuemei Song, Li Liu, Weidan Pu, Tongjian Bai, Huaning Wang, Hong Yin, Kai Wang, Lingjiang Li, Dewen Hu +14 morewiley +1 more sourceExpandable Nanocomposite Shape‐Memory Hemostat for the Treatment of Noncompressible Hemorrhage
Advanced Science, EarlyView.A nanocomposite‐coated shape memory foam rapidly expands, accelerates clotting, and reduces blood loss in vivo. Its fast volumetric expansion and strong procoagulant activity make it a promising hemostat for treating deep, noncompressible hemorrhage.Saptarshi Biswas, Sarah E. Miller, Shounak Roy, Jeevika Thazhaiselvam, Samantha Foster, Manivannan Sivaperuman Kalairaj, Sasha M. George, Yava Jones‐Hall, Staci J. Horn, Fred J. Clubb, Taylor H. Ware, Duncan J. Maitland, Akhilesh K. Gaharwar +12 morewiley +1 more sourceDiscovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice
Advanced Science, EarlyView.The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract
Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu +15 morewiley +1 more sourceMammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA
Advanced Science, EarlyView.We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...Lena Engelhard, Zeyneb Vildan Cakil, Marlon S. Zambrano‐Mila, Simone Eppmann, Tye Gonzalez, Rasmus Linser, Petra Janning, Sidney Becker, Daniel Summerer +8 morewiley +1 more sourceA Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors
Advanced Science, EarlyView.This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng +10 morewiley +1 more source
