Results 241 to 250 of about 25,564,378 (356)

Engineering Bacteria as Living Therapeutics in Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen   +6 more
wiley   +1 more source

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

open access: yesAdvanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng   +14 more
wiley   +1 more source

Produção de sementes de mandioca em plantas com um e dois ciclos vegetativos [PDF]

open access: gold, 1984
Domingos Antônio Monteiro   +4 more
openalex   +1 more source

Transposable elements as key regulators of placental development. [PDF]

open access: yesVavilovskii Zhurnal Genet Selektsii
Zhilkina MA, Tolmacheva EN, Vasilyev SA.
europepmc   +1 more source

Metabolic Interplay in Acute Lung Injury: PARK7 Integrates FADS1/2‐Dependent PUFA Metabolism and H3K14 Lactylation to Attenuate Endothelial Ferroptosis and Dysfunction

open access: yesAdvanced Science, EarlyView.
SCAP/ARDS patients show reduced unsaturated fatty acids (UFAs) but higher PARK7 and lactate in plasma. PARK7 correlates positively with lactate and negatively with UFAs. Pulmonary endothelial cell multi‐omics show FADS1/2 downregulation and impaired PUFA metabolism. Lactate boosts PARK7 via H3K14 lactylation, and PARK7 then restores FADS1/2.
Jian Xu   +11 more
wiley   +1 more source

Anemias em crianças de dois serviços de saúde de Recife, PE (Brasil) [PDF]

open access: gold, 1985
Aurení Costa Salzano   +3 more
openalex   +1 more source

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