Results 121 to 130 of about 1,205,127 (273)

Discordance of Dopaminergic Dysfunction and Subcortical Atrophy by α‐Synuclein Status in Sporadic and Genetic Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Parkinson's disease (PD) is characterized by predominantly neuronal α‐synuclein pathology and dopaminergic dysfunction. Cerebrospinal fluid (CSF) seeding amplification assays (SAA) detect α‐synuclein aggregates in vivo, but not all patients with PD have a positive SAA.
Michael Tran Duong, Sandhitsu R. Das, Pulkit Khandelwal, Joaquin A. Vizcarra, Yue Li, Long Xie, Paul A. Yushkevich, Leslie M. Shaw, Jacob G. Dubroff, Parkinson's Progression Markers Initiative, Kenneth Marek, Shirley Lasch, Caroline Tanner, Tanya Simuni, Christopher Coffey, Karl Kieburtz, Renee Wilson, Brit Mollenhauer, Site Investigator, Douglas Galasko, Site Investigator, Tatiana Foroud, Lana Chahine, Andrew Siderowf, John Seibyl, Arthur Toga, Andrew Singleton, Daniel Weintraub, John Trojanowski, Leslie Shaw, Duygu Tosun‐Turgut, Kathleen Poston, Susan Bressman, Kalpana M. Merchant, Werner Poewe, Todd Sherer, Sohini Chowdhury, Mark Frasier, Catherine Kopil, Anna Naito, Vanessa Arnedo, Ray Dorsey, Cynthia Casaceli, Imaging Core, Nichole Daegele, Justin Albani1 Statistics Core, Chelsea Caspell‐Garcia, Liz Uribe, Eric Foster, Jeff Long, Nick Seedorff, Karen Crawford, Danielle Elise Smith, Paola Casalin, Giulia Malferrari, Cheryl Halter, David Russell, Stewart Factor, Penelope Hogarth, David Standaert, Amy Amara, Robert Hauser, Joseph Jankovic, Matthew Stern, Shu‐Ching Hu, Gretchen Todd, Rachel Saunders‐Pullman, Irene Richard, Marie H Saint‐Hilaire, Klaus Seppi, Holly Shill, Hubert Fernandez, Claudia Trenkwalder, Wolfgang Oertel, Daniela Berg, Kathrin Brockman, Isabel Wurster, Liana Rosenthal, Yen Tai, Nicola Pavese, Paolo Barone, Stuart Isaacson, Alberto Espay, Dominic Rowe, Melanie Brandabur, James Tetrud, Grace Liang, Alex Iranzo, Eduardo Tolosa, Karen Marder, Maria de Arriba Sanchez, Leonidis Stefanis, Maria Jose Marti, Javier Ruiz Martinez, Jean‐Christophe Corvol, Jan O Assly, Salima Brillman, Nir Giladi, Debra Smejdir, Julia Pelaggi, Farah Kausar, Linda Rees, Barbara Sommerfield, Madeline Cresswell, Courtney Blair, Karen Williams, Grace Zimmerman, Stephanie Guthrie, Ashlee Rawlins, Leigh Donharl, Christine Hunter, Baochan Tran, Abigail Darin, Carly Linder, Marne Baca, Heli Venkov, Cathi‐Ann Thomas, Raymond James, Beatrice Heim, Paul Deritis, Fabienne Sprenger, Deborah Raymond, Diana Willeke, Zoran Obradov, Jennifer Mule, Nancy Monahan, Katharina Gauss, Deborah Fontaine, Daniel Szpak, Arita McCoy, Becky Dunlop, Laura Marie Payne, Susan Ainscough, Lisbeth Carvajal, Rebecca Silverstein, Kristy Espay, Madelaine Ranola, Elisabet Mondragon Rezola, Helen Mejia Santana, Maria Stamelou, Alicia Garrido, Stephanie Carvalho, Anne Grete Kristiansen, Krista Specketer, Anat Mirlman, Maurizio Facheris, Holly Soares, Mark A. Mintun, Jesse Cedarbaum, Peggy Taylor, Danna Jennings, Lawrence Slieker, Brian McBride, Colin Watson, Etienne Montagut, Zulfiqar Haider Sheikh, Baris Bingol, Remi Forrat, Pablo Sardi, Tanya Fischer, Alastair D. Reith, Jan Egebjerg, Lone Frydelund Larsen, Nathalie Breysse, Didier Meulien, Barbara Saba, Vera Kiyasova, Chris Min, Thomas McAvoy, Robert Umek, Philip Iredale, Jeremy Edgerton, Susan De Santi, Christian Czech, Frank Boess, Jeffrey Sevigny, Thomas Kremer, Igor Grachev, Kaplana Merchant, Andreja Avbersek, Pierandrea Muglia, Alexandra Stewart, Rene Prashad, Johannes Taucher, Andrew Siderowf, David A. Wolk, Ilya M. Nasrallah   +186 more
wiley   +1 more source

Heavy metals trigger distinct molecular transformations in microplastic-versus natural-derived dissolved organic matter

Environmental Science and Ecotechnology
Dissolved organic matter (DOM) is a key determinant of heavy metal fate in aquatic environments, influencing their mobility, toxicity, and bioavailability.
Xianbao Zhong, Kaiying Zhao, Mengyuan Wu, Yaohui Zhang, Chiyue Ma, Hexiang Liu, Bokun Chang, Xiaohui Lian, Yujing Li, Zixuan Huang, Lang Zhu, Ming Zhang, Chi Zhang, Yajun Yang, Jialong Lv   +14 more
doaj   +1 more source

Combining social, ecological and economic approaches in knowledge co‐production enables the identification of sustainable farming options

People and Nature, EarlyView.
Abstract Farming systems face an increasing sustainability challenge requiring integrated solutions to minimize the trade‐offs between the social, ecological and economic dimensions of sustainability. Yet, most research remains siloed, limiting interdisciplinary understanding of farming systems as coupled social‐ecological systems (SESs) and precluding
Neema R. Kinabo, Dominic A. Martin, Koggani D. Koggani, Berta Martín‐López, Milena Gross, Christian Schleyer, Verena Hackmann, Andreas Thiel, Katrin Böhning‐Gaese, Peter Manning   +9 more
wiley   +1 more source

Permafrost Mass Wasting in Ice‐Rich Landscapes: Recent Advances (2013 to 2024) on Mechanisms, Dynamics and Impacts

Permafrost and Periglacial Processes, EarlyView.
ABSTRACT Across circumpolar permafrost regions, climate change is destabilizing ice‐rich hillslopes, increasing the frequency and magnitude of thaw‐driven mass wasting. This paper reviews recent studies (2013–2024) on thaw‐driven mass wasting, focusing on the processes, morphology and trajectories of geomorphic change and their implications for ...
J. M. Young, L. Farquharson, J. Luo, N. Nesterova, J. van der Sluijs, S. V. Kokelj   +5 more
wiley   +1 more source

Unraveling the Molecular Composition and Reactivity Differentiation of Algae- and Macrophyte-Derived Dissolved Organic Matter in Plateau Lakes: Insights from Optical Properties and High Resolution Mass Spectrometry Characterization

Molecules
Most lacustrine dissolved organic matter (DOM) still lacks comprehensive environmental sources and molecular characterization, especially in plateau lakes.
Qiuxing Li, Runyu Zhang, Haijun Yuan, Liying Wang, Shuxia Xu   +4 more
doaj   +1 more source

Evaluation of a High‐Performance Monopropellant Formed of Microencapsulated Hydrocarbon Fuels in Combination With Gelled Hydrogen Peroxide in a Strand Burner Setup

Propellants, Explosives, Pyrotechnics, EarlyView.
A high‐performance premixed monopropellant is prepared from hydrocarbon‐filled microcapsules and hydrogen peroxide. This propellant is burned in a strand burner, and the effect of different parameters on the burn rate is evaluated. ABSTRACT A dispersion of hydrocarbon‐fuel‐filled microcapsules in gelled hydrogen peroxide can form a premixed ...
Robin Scholl, Felicitas S. Moll, Dominic Freudenmann, Stefan Schlechtriem   +3 more
wiley   +1 more source

Picky Eaters: Carbon Isotopic Evidence for the Uniform Bioavailability of Riverine Dissolved Organic Matter to a Model Marine Microorganism

Geophysical Research Letters
Dissolved organic matter (DOM) is a key component of the global carbon cycle, with rivers delivering significant amounts of DOM to oceans. Urbanization and agricultural land‐use alter the age and chemical composition of riverine DOM, which likely impact ...
Lea Baumser, Lindsey Potts, Brett D. Walker, Nagissa Mahmoudi   +3 more
doaj   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Advancing Sclerotinia risk forecasting for winter rapeseed in Germany: integrating crop phenology and disease development into a decision support system

Pest Management Science, EarlyView.
Integrating crop phenology and sclerotia germination models into SkleroPro improved Sclerotinia risk prediction accuracy from 34% to 66%, optimizing fungicide timing and supporting sustainable winter rapeseed production. Abstract BACKGROUND Sclerotinia stem rot, caused by Sclerotinia sclerotiorum, threatens winter rapeseed (Brassica napus) production ...
Vera Krause, Nazanin Zamani‐Noor, Lena Müller, Hella Kehlenbeck, Anto Raja Dominic   +4 more
wiley   +1 more source

Construction of an O2‐responsive engineering bioreactor for enhanced indole‐3‐propionic acid production and deoxynivalenol detoxification

Responsive Materials, EarlyView.
An oxygen‐responsive living bioreactor was engineered via interspecies protoplast fusion, converting oxygen from an inhibitory stress into a programmable signal for sustained indole‐3‐propionic acid (IPA) production. This genetically encoded bioreactor enables robust aerobic operation and therapeutic efficacy of deoxynivalenol detoxification in vivo ...
Ning Ma, Jiakun Shen, Kun Cai, Wenxi Zhao, Chuan Feng, Xingyao Wang, Yangyang Liu, Dongyan Zhang, Xi Ma   +8 more
wiley   +1 more source