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Results 231 to 240 of about 123,703 (303)

Hydrostatic pressure induces strong leakage of dissolved organic matter from "marine snow" particles. [PDF]

Sci Adv
Stief P +7 more
europepmc +1 more source

Advancing Early‐Stage Type 1 Diabetes Care: Future Focused Pathways for Identification, Screening, Diagnosis, and Monitoring

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Although international guidelines provide recommendations for screening and monitoring of early‐stage type 1 diabetes (T1D), navigating the care pathway can still be difficult for individuals, caregivers, and healthcare professionals (HCPs). These challenges are exacerbated by variations in healthcare systems, gaps in communication,
Chantal Mathieu +14 more
wiley +1 more source

A Phase 2 Trial of Frexalimab, a CD40L Antagonist, in Adolescents and Adults With Recent‐Onset Type 1 Diabetes (FABULINUS): Rationale and Study Design

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune disease, characterised by progressive destruction of the insulin‐producing pancreatic β‐cells. Preserving remaining β‐cells at the time of diagnosis may improve long‐term outcomes. Frexalimab is a humanised monoclonal antibody specific for CD40L undergoing evaluation for treatment of ...
Andriy Cherkas +11 more
wiley +1 more source

Reciprocal targeting of the unfolded protein response regulator Xbp1 and the DOM-A nucleosome remodeler in Drosophila. [PDF]

Nucleic Acids Res
Kars G, Becker PB, Apostolou Z.
europepmc +1 more source

Short- and Long-Acting Psychedelics: Structure-Activity Relationships, Pharmacology, and Implications for Neuropsychiatric Therapeutics. [PDF]

ACS Chem Neurosci
Bhat A +6 more
europepmc +1 more source

Diabetic Peripheral Neuropathy May Be an Independent Risk Marker for Dementia and Cerebrovascular Disease

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Diabetic peripheral neuropathy (DPN) may be linked to central nervous system changes. This study examined if DPN is associated with an increased risk of incident dementia and cerebrovascular disease in individuals with Type 1 (T1D) and Type 2 diabetes (T2D). Materials and Methods This register‐based cohort study (1998–2020) used data from
Astrid Wiggers +9 more
wiley +1 more source

The ocean's biological carbon pump under pressure. [PDF]

Sci Adv
Middelburg JJ.
europepmc +1 more source

Body Mass Index and All‐Cause, Cancer, and Cardiovascular Mortality in Adults Aged 16–50 Years With and Without Type 2 Diabetes: An Analysis of Primary Care Records in England

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To examine the association between body mass index (BMI) and risk of all‐cause, cancer, and cardiovascular diseases (CVD) mortality among adults aged 16–50 years with and without type 2 diabetes (T2D). Materials and Methods We conducted a retrospective matched cohort study using primary care records from the Clinical Practice Research ...
Yijing Chen +6 more
wiley +1 more source

Dissolved Organic Matter in the Coastal Ocean Is Structurally More Diverse Than in Terrestrial Systems, as Shown in an Amazonian Mangrove Estuary. [PDF]

Environ Sci Technol
Mitschke N, Dittmar T, Seidel M.
europepmc +1 more source

Underdiagnosed and Undertreated: Obesity and Its Cardiometabolic Burden in Swedish Clinical Practice—Insights From the AROS Database

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To quantify real‐world diagnosis and treatment of obesity in Sweden, describe cardiometabolic comorbidity burden across obesity classes, and compare long‐term cardiovascular outcomes with the general population. Materials and Methods This population‐based cohort study used the AROS (Analysis of Real‐world data of patients with Obesity in ...
Viveca Ritsinger +6 more
wiley +1 more source

dissolved organic matter
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