Results 131 to 140 of about 8,741,639 (312)
SPADE: spatial deconvolution for domain specific cell-type estimation
Communications BiologyUnderstanding gene expression in different cell types within their spatial context is a key goal in genomics research. SPADE (SPAtial DEconvolution), our proposed method, addresses this by integrating spatial patterns into the analysis of cell type ...
Yingying Lu, Qin M. Chen, Lingling An
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
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Domain-specific metamodels for heterogeneous information systems
, 2003 Domain-specific metamodels for heterogeneous information ...
J Tan (9855881) +3 more
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Genes, proteins and domain-specificity
Trends in Cognitive Sciences, 1999 In their response to van der Lely et al.1xEvidence for a grammar-specific deficit in children. van der Lely, H., Rosen, S., and McClelland, A. Curr. Biol. 1998; 8: 1253–1258Abstract | Full Text | Full Text PDF | PubMedSee all References1, Tomblin and Pandich appear to doubt the possibility that ‘specific aspects of language content’ are ‘under specific
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A Metamodel Based Approach for UML Notated Domain Specific Modelling Language
This paper focuses on a metamodel based approach to Unified Modelling Language (UML systems modelling and simulation. The approach allows creating a system model by operating with artefacts from the problem domain.
Krasts, Ojārs +3 more
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
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, 2011 Two studies that examine whether the forgetting caused by the processing demands of working memory tasks is domain-general or domain-specific are presented. In each, separate groups of adult participants were asked to carry out either verbal or nonverbal
Harvey, Caroline E. +7 more
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
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