Results 211 to 220 of about 8,741,639 (312)

The Association Between Physical Activity and Domain-Specific Cognitive Function in the Elderly: A Cross-Sectional Study and Genetic Analysis. [PDF]

Brain Behav
Yin X, Peng H, Li Y, Song Y, Chen L, Yao N, Li P, He Z, Chen H, Huang L, Shen Z, Chen Q.   +11 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Domain-Specific Paradox of Physical Activity and Depression Among Patients With Cardiovascular Disease or Related Conditions. [PDF]

J Am Heart Assoc
Yeon SJ, Byeon JY, Lee DH, Jae SY, Lee CJ, Jeong A, Jeon JY.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

899 emObject: domain specific data abstraction for spatial omics

Journal for ImmunoTherapy of Cancer, 2023
Aaron Mayer, Alexandro E Trevino, Ethan Baker   +2 more
doaj   +1 more source

Towards precision vibration therapy for poststroke balance: a domain-specific systematic review and meta-analysis protocol. [PDF]

BMJ Open
Kim JD, Park SR, Chun JM, Seok JW, Seo JW.   +4 more
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Development and comparative evaluation of knowledge graph-enhanced large language models for domain-specific question answering in nursing. [PDF]

BMC Nurs
Shi J, Chen H, Shi C, Su C, Yue S, Li W, Liu X, Zhou Y, Zhong Y, Chen B, Sun C, Sang K, Li Z.   +12 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

MedDiscover: A Domain-Specific Retrieval-Augmented Generation Framework for Evidence-Grounded Knowledge Extraction in Metabolomics. [PDF]

Comput Struct Biotechnol J
Patel VP, Jolkver E, Schwerk A.
europepmc   +1 more source