Results 31 to 40 of about 2,458,322 (294)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Abstract robust coarse spaces for systems of PDEs via generalized eigenproblems in the overlaps [PDF]
, 2013 Coarse spaces are instrumental in obtaining scalability for domain decomposition methods for partial differential equations (PDEs). However, it is known that most popular choices of coarse spaces perform rather weakly in the presence of heterogeneities ...
Dolean Maini, Victorita +5 more
core +4 more sources
Fractal and FractionalWe consider a non-overlapping domain decomposition method for optimal control problems of the tracking type governed by time-fractional diffusion equations in one space dimension, where the fractional time derivative is considered in the Caputo sense. We
Günter Leugering +2 more
doaj +1 more source
Time integration and the Trefftz Method Part I - First-order and parabolic problems
Computer Assisted Methods in Engineering and Science, 2023 The finite element method is applied in the time domain to establish formulations for the integration of first-order and parabolic (transient) problems. The modal decomposition concept is applied using two distinct approaches.
João A. Teixeira de Freitas
doaj
Triangular Decomposition of Matrices in a Domain [PDF]
, 2015 Deterministic recursive algorithms for the computation of matrix triangular decompositions with permutations like LU and Bruhat decomposition are presented for the case of commutative domains. This decomposition can be considered as a generalization of LU and Bruhat decompositions, because they both may be easily obtained from this triangular ...
Gennadi I. Malaschonok, Anton Scherbinin
openaire +3 more sources
Space-Time Balancing Domain Decomposition [PDF]
SIAM Journal on Scientific Computing, 2017 In this work, we propose two-level space-time domain decomposition preconditioners for parabolic problems discretized using finite elements. They are motivated as an extension to space-time of balancing domain decomposition by constraints preconditioners.
Santiago Badia, Marc Olm
openaire +6 more sources
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Mechanical Engineering JournalIn this study, a parallel three-scale homogenization analysis simulator that accounts for macro-, meso-, and micro-scale structures was developed for the carbon-fiber-reinforced plastics (CFRPs) used in high-pressure hydrogen storage vessels manufactured
Naoki MORITA +5 more
doaj +1 more source
Domain Decomposition Methods in Feel++ [PDF]
, 2014 This paper presents our ongoing work on building a versatile domain decomposition methods framework in Feel++ that provides expressivity (e.g. closeness to the mathematical language) and efficiency. We display in particular the capabilities of Feel++ regarding Schwarz (non)overlapping and mortar methods.
Samake, Abdoulaye +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source