Results 161 to 170 of about 259,102 (312)
Journal of MathematicsThe mixed BVP for a compressible Stokes system of PDEs with variable viscosity is considered in a bounded domain of three dimensions. Based on a specially constructed parametrix (Levi function), the problem is reduced to the united boundary-domain ...
Goitom W. Hagos, Tsegaye G. Ayele
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
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Duality in Noetherian Integral Domains
Rocky Mountain Journal of Mathematics, 1999 Let \(A\) be a torsion-free abelian group of rank one and let \(C(A)\) denote the class of torsion-free abelian groups \(M\) of finite rank such that \(M\) embeds as \(\text{End}(A)\)-submodule of \(A^n\) for some \(n\). Then the map \(M\) to \(\Hom(M,A)\) on \(C(A)\) defines a duality. This is called Warfield duality. In this paper, the author gives a
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
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VibrationThe development of simple and yet accurate formulations of frequency–amplitude relationships for non-conservative nonlinear oscillators is an important issue.
Chein-Shan Liu +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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THE REPRESENTATION OF THE GENERALIZED DIFFERENTIAL OPERATOR IN SOME CLASS OF THE STAR SHAPED DOMAIN
Вестник Донского государственного технического университета, 2018 The author have got an integral representation of the Gel’fond – Leont’ev generalized differential and integral operators in the space of analytic functions in the star shaped with respect to the zero domain.
A.V. MORZHAKOV
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
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