Results 91 to 100 of about 4,810,145 (339)

On the Effective Configuration of Planning Domain Models [PDF]

open access: yes, 2015
The development of domain-independent planners within the AI Planning community is leading to “off the shelf” technology that can be used in a wide range of applications.
Chrpa, Lukáš   +3 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

A sound strategy for homology modeling-based affinity maturation of a HIF-1α single-domain intrabody [PDF]

open access: gold, 2020
Min Hu   +7 more
openalex   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Domain-Specific Model Editors with Model Completion [PDF]

open access: yes, 2008
Today, integrated development environments such as Eclipse allow users to write programs quickly by presenting a set of recommendations for code completion. Similarly, word processing tools such as Microsoft Word present corrections for grammatical errors in sentences.
Sen, Sagar   +2 more
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates Retinitis Pigmentosa and Enhanced S-cone Syndrome models [PDF]

open access: gold, 2020
Izarbe Aísa-Marín   +6 more
openalex   +1 more source

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