Results 161 to 170 of about 4,810,145 (339)

Cross-Domain Object Matching with Model Selection [PDF]

, 2010
Makoto Yamada, Masashi Sugiyama
openalex  

Optimizing Numerical Estimation and Operational Efficiency in the Legal Domain through Large Language Models [PDF]

Jia-Hong Huang, Chao-Chun Yang, Yixian Shen, Alessio M. Pacces, Evangelos Kanoulas   +4 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Pre- and Post-processing Strategies for Generic Slice-wise Segmentation of Tomographic 3D Datasets Utilizing U-Net Deep Learning Models Trained for Specific Diagnostic Domains

, 2020
Gerald Zwettler, Werner Backfrieder, David R. Holmes   +2 more
openalex   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Fusing Vector Space Models for Domain-Specific Applications [PDF]

, 2019
Laura Rettig, Julien Audiffren, Philippe Cudré-Mauroux   +2 more
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Computationally Efficient Implementation of Aperture Domain Model Image Reconstruction. [PDF]

IEEE Trans Ultrason Ferroelectr Freq Control, 2019
Dei K, Schlunk S, Byram B.
europepmc   +1 more source

Injecting Domain-Specific Knowledge into Large Language Models: A Comprehensive Survey [PDF]

Zhihua Song, Bin Yan, Yuhan Liu, Miao Fang, Mingzhe Li, Rui Yan, Xiuying Chen   +6 more
openalex   +1 more source