Results 171 to 180 of about 4,810,145 (339)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The Longevity Medicine Patient Experience Framework: A Seven-Domain Model for Optimizing Person-Centered Longevity Medicine. [PDF]

J Patient Exp
Osório TG, Robertson-Malt S, McGrath R, Qureshi N, Lee-St John T, Cassidy L, Pena-Acuna V, Buckley L, Piechowski-Jozwiak B, Sirotin N.   +9 more
europepmc   +1 more source

Mixture Models for Domain-Adaptive Brain Decoding [PDF]

Aidan Dempster, Brokoslaw Laschowski
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

A Technique to Track Scatterers for Continuous High-speed Plane-wave Ultrasound Simulations based on a Fluid Domain Model. [PDF]

IEEE Open J Ultrason Ferroelectr Freq Control
Ketterling JA, Wahyulaksana G, Bazzi MS, Wiputra H.   +3 more
europepmc   +1 more source

Lagging-Domain Model for Compensation of Hysteresis of xMR Sensors in Positioning Applications. [PDF]

Sensors (Basel), 2018
Domajnko D, Križaj D.
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Proposal of a domain model for 3D representation of buildings in Ecuador. [PDF]

F1000Res
Velastegui Cáceres LA, Velastegui Cáceres JD, Carretero Poblete PA, Moyón Gusqui MF, Cevallos Díaz MA.   +4 more
europepmc   +1 more source

Frequency domain model for transient analysis of lightning protection systems of buildings. [PDF]

Heliyon, 2016
Gómez P.
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source