Results 51 to 60 of about 4,810,145 (339)

Modelo de contexto y de dominio para la ingeniería de requisitos de sistemas ubicuos Context model and domain model for requirements engineering ubiquitous systems

Revista Ingenierías Universidad de Medellín, 2010
Este artículo presenta los modelos de contexto y de dominio de un ambiente ubicuo genérico, como instrumento para facilitar la transición del conocimiento de la fase de definición a la fase de análisis y servir de base para la obtención de los requisitos.
Liliana González Palacio, Germán Urrego Giraldo   +1 more
doaj  

Multi-Model Domain Adaptation for Diabetic Retinopathy Classification

Frontiers in Physiology, 2022
Diabetic retinopathy (DR) is one of the most threatening complications in diabetic patients, leading to permanent blindness without timely treatment. However, DR screening is not only a time-consuming task that requires experienced ophthalmologists but ...
Guanghua Zhang, Guanghua Zhang, Bin Sun, Zhaoxia Zhang, Jing Pan, Weihua Yang, Yunfang Liu   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Large N Domain Walls as D-branes for ${\cal N}=1$ QCD String

, 1998
We consider a model which in a certain limit reduces to the large N ${\cal N}=1$ supersymmetric SU(N) gauge theory without matter. The gaugino condensate in this model is controlled by the dynamics of an additional singlet superfield. Using this model we
Amati, Bershadsky, Carroll, Cecotti, Cecotti, Cecotti, Chibisov, Dvali, Dvali, Dvali, Fendley, Fendley, Gia Dvali, Hooft, Intriligator, Intriligator, Kakushadze, Kogan, Kovner, Kovner, LeClair, Lerche, Lerche, Martinec, Novikov, Novikov, Polchinski, Polyakov, Seiberg, Shifman, Shifman, Shifman, Shifman, Shifman, Smilga, Smilga, Taylor, Vafa, Veneziano, Witten, Zurab Kakushadze   +40 more
core   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Federated Large Domain Model System

Blockchain: Research and Applications
As organizations increasingly seek to build Foundation Models (FMs) using their own proprietary data, many are adopting private and in-house cloud infrastructures (often in addition to public clouds) to address concerns over cost, data privacy, and data ...
Chunming Rong, Jungwon Seo, Zihan Zhao, Ferhat Ozgur Catak, Jiahui Geng, Martin Gilje Jaatun   +5 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Semantics of the maturity model for feature oriented domain analysis [PDF]

Computational Ecology and Software, 2015
Assessing the quality of a model has always been a challenge for researchers in academia and industry. The quality of a feature model is a prime factor in software development because it is used in the development of products.
M. Javed, M. Naeem, H. A. Wahab
doaj  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source