Results 211 to 220 of about 10,126,895 (308)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

ANO5 p.I616F variant drives florid cemento-osseous dysplasia by disrupting transmembrane domain structure. [PDF]

BMC Oral Health
Zhang L, Jin W, Qin Y, Zhang Y, Qian Y, Li J, Liu Y, Shi Y, Xie R, Wang W.   +9 more
europepmc   +1 more source

Domain Structure, Thermal and Mechanical Properties of Polycaprolactone-Based Multiblock Polyurethane-Ureas under Control of Hard and Soft Segment Lengths. [PDF]

Polymers (Basel), 2022
Bugrov AN, Gorshkova YE, Ivan'kova EM, Kopitsa GP, Pavlova AA, Popova EN, Smirnova VE, Smyslov RY, Svetlichnyi VM, Vaganov GV, Vasil'ev BV.   +10 more
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Insights into therapeutic discovery through the Kelch domain structure of Keap1 at ambient temperature. [PDF]

Turk J Biol
Yilmaz M, Sever B, Kutlu Y, Gül M, Okuducu C, Tavli S, Otsuka M, Fujita M, Haliloğlu T, Çiftçi H, Demirci H, Demirci H.   +11 more
europepmc   +1 more source

Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice. [PDF]

Front Immunol, 2023
Pflumm D, Seidel A, Klein F, Groß R, Krutzke L, Kochanek S, Kroschel J, Münch J, Stifter K, Schirmbeck R.   +9 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Constructing a Broad-Pore-Domain Structure of Adsorbents for Acteoside Adsorption. [PDF]

Polymers (Basel)
Ru W, Liu J, Xiong F, Sun Y, Zhang Y, Li Y, Lv Y, Li X.   +7 more
europepmc   +1 more source

Missense Mutations in Desmoplakin Plakin Repeat Domains Have Dramatic Effects on Domain Structure and Function. [PDF]

Int J Mol Sci, 2022
Mohammed F, Odintsova E, Chidgey M.
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source