Results 251 to 260 of about 1,858,236 (277)
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Domain Swapping in the Cytoplasmic Domain of the Escherichia coli Rhomboid Protease
Journal of Molecular Biology, 2013Rhomboids are membrane-embedded serine proteases that cleave membrane protein substrates. Escherichia coli rhomboid GlpG (ecGlpG) consists of an N-terminal cytoplasmic domain and a membrane domain containing the active site. We determined the crystal structure of the soluble cytoplasmic domain of ecGlpG at 1.35Å resolution and examined whether this ...
Christelle, Lazareno-Saez +3 more
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Domain swapping of CD4 upon dimerization
Proteins: Structure, Function, and Bioinformatics, 2004AbstractIt has recently been shown that disulfide bond Cys130—Cys159 in domain 2 of monomeric CD4 is involved in the formation of CD4 disulfide‐bonded dimers on cell surfaces and that it can influence the permissiveness of cells to HIV infection. Because this disulfide bond is buried in the monomer, a large conformational change must take place in ...
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Nucleation process in the folding of a domain-swapped dimer
Physical Review E, 2010Nucleation processes are important for the understanding in protein dynamics. To evaluate the effect of nucleation mechanism in dimerization process, a domain-swapped dimer (Esp8) is simulated with the symmetrized Gō model and the classical Gō model. The pathways of the dimerization are analyzed with computational phi -analysis method.
Zhiqiang, Yan +4 more
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Domain Swaps to Phenotype Shifts
Science Signaling, 2010Systematic swapping of modular protein domains verifies a mechanism for generation of phenotypic diversity in yeast.
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Structure of infectious prions: stabilization by domain swapping
The FASEB Journal, 2005ABSTRACT A candidate structure for the minimal prion infectious unit is a recently discovered protein oligomer modeled as a β‐helical prion trimer (BPT); BPTs can stack to form cross‐β fibrils and may provide insight into protein aggregates of other amyloid diseases.
Sichun, Yang +3 more
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Three-dimensional domain duplication, swapping and stealing
Current Opinion in Structural Biology, 1997Examination of multidomain and/or multimeric protein structures can reveal evolutionary paths to a more complex 3D organization. Over the past few years, proteins have been shown to evolve while preserving mutual domain organization and interfaces. The recent advances in understanding domain reorganization and mobility highlight the versatility and ...
J, Heringa, W R, Taylor
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Domain-swapped structure of a mutant of cyanovirin-N
Biochemical and Biophysical Research Communications, 2002Cyanovirin-N (CV-N) is a potent 11 kDa HIV-inactivating protein that binds with high affinity to the HIV surface envelope protein gp120. A double mutant P51S/S52P of CV-N was engineered by swapping two critical hinge-region residues Pro51 and Ser52. This mutant has biochemical and biophysical characteristics equivalent to the wild-type CV-N and its ...
Istvan, Botos +4 more
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Comparison of backbone dynamics of monomeric and domain‐swapped stefin A
Proteins: Structure, Function, and Bioinformatics, 2004AbstractThree‐dimensional domain swapping has been observed in increasing number of proteins and has been implicated in the initial stages of protein aggregation, including that of the cystatins. Stefin A folds as a monomer under native conditions, while under some denaturing conditions domain‐swapped dimer is formed.
Japelj, Boštjan +2 more
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Domain swapping of death domain superfamily: Alternative strategy for dimerization
International Journal of Biological Macromolecules, 2019The role of death domain (DD) protein-mediated inter-protein interactions in cell death and immune cell signaling have been extensively investigated as they are tentative targets for therapeutic interventions and are involved in signal transduction. Structural studies, especially those involving the recent advanced cryo-electron microscopy, indicated ...
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TCX: Texture and Channel Swappings for Domain Generalization
SSRN Electronic Journal, 2022Jaehyun Choi +3 more
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