Results 41 to 50 of about 146,080 (269)

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Planning urban pavement maintenance by a new interactive multiobjective optimization approach

European Transport Research Review, 2019
Pavement maintenance is essential to prevent the deterioration of asset value and to satisfy the expectations of all stakeholders (objectives). However, the budgets are often insufficient to keep the road pavement at optimum levels. Therefore, a decision
Maria Grazia Augeri, Salvatore Greco, Vittorio Nicolosi   +2 more
doaj   +1 more source

Local Chirality of Low-Lying Dirac Eigenmodes and the Instanton Liquid Model [PDF]

, 2002
The reasons for using low-lying Dirac eigenmodes to probe the local structure of topological charge fluctuations in QCD are discussed, and it is pointed out that the qualitative double-peaked behavior of the local chiral orientation probability ...
A. A. Belavin, A. Hasenfratz, A. M. Polyakov, A. M. Polyakov, B. Berg, B. Bunk, C. Callan, C. G. Callan, C. Gattringer, C. Gattringer, C. Gattringer, C. Michael, D. I. Diakonov, D. I. Diakonov, D. Pugh, E. V. Shuryak, E. Witten, E. Witten, F. X. Lee, G. ’t Hooft, G. ’t Hooft, H. B. Thacker, H. Neuberger, H. Neuberger, I. Hip, I. Horváth, I. Horváth, I. Horváth, I. Horváth, I. Horváth, J. B. Zhang, J. Hoek, J. Hoek, J. McCune, J. Smit, J. Smit, K. F. Liu, M. Albanese, M. Atiyah, M. C. Chu, M. Falcioni, M. G. Pérez, M. Guagnelli, M. I. Polikarpov, M. Laursen, M. Lüscher, M. Okamoto, M. Teper, N. Isgur, P. de Forcrand, R. Edwards, R. G. Edwards, R. Jackiw, S. J. Dong, S. J. Dong, S. J. Dong, T. Banks, T. Blum, T. DeGrand, T. DeGrand, T. DeGrand, T. Draper, T. Kalkreuter, T. Schäfer, Y. Iwasaki   +64 more
core   +5 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Remarks on the Gribov Problem in Direct Maximal Center Gauge [PDF]

, 2001
We review the equivalence of maximal center gauge fixing to the problem of finding the best fit, to a given lattice gauge field, by a thin vortex configuration. This fit is necessarily worst at the location of P-plaquettes.
G. Bali, Jeff Greensite, K. Langfeld, K. Langfeld, L. Del Debbio, M. Engelhardt, M. Faber, M. Faber, M. Ogilvie, Manfried Faber, Ph. de Forcrand, Ph. de Forcrand, Ph. de Forcrand, R. Bertle, T. Kovács, T. Kovács, V. Bornyakov, V. Bornyakov, Štefan Olejník   +18 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Polarizations of J/\psi and \psi' in hadroproduction at Tevatron in the k_t factorization approach

, 2001
We present a calculation for the polarizations of $J/\psi$ and $\psi'$ produced in the hadron collisions at the Fermilab Tevatron. Various color octet channels including ${}^1S_0^{(8)}$, ${}^3P_J^{(8)}$, and ${}^3S_1^{(8)}$ as well as contributions from $
B. A. Kniehl, C. Y. Wong, E. Braaten, E. Braaten, E. M. Levin, E. M. Levin, F. Abe, F. Abe, F. Abe, F. Abe, F. Yuan, F. Yuan, Feng Yuan, G. T. Bodwin, G. T. Bodwin, J. C. Collins, J. Kwiecinski, Kuang-Ta Chao, M. Beneke, M. Cacciari, M. G. Ryskin, M. G. Ryskin, P. Cho, P. Cho, P. Hägler, P. Hägler, P. Hägler, S. Catani, S. Catani, S. P. Baranov, S. P. Baranov, S. P. Baranov, T. Affolder   +32 more
core   +1 more source

Preference learning based decision map algebra: specification and implementation [PDF]

, 2019
Decision Map Algebra (DMA) is a generic and context independent algebra, especially devoted to spatial multicriteria modelling. The algebra defines a set of operations which formalises spatial multicriteria modelling and analysis. The main concept in DMA
Abubahia, Ahmed, Chakhar, Salem, Cocea, Mihaela   +2 more
core   +1 more source

Breast Cancer and Aging: Understanding the Complex Relationship and Implications for Prevention and Screening

Aging and Cancer, EarlyView.
ABSTRACT Background Breast cancer is a multifactorial disease that affects many women worldwide. Age is the most important risk factor for breast cancer, with an increased incidence markedly after the age of 50. The relationships of aging to breast cancer have been thoroughly examined, and notable connections regarding various age‐related changes in ...
Mehran Radak, Armin Sharifi, Derek Richard, Hossein Fallahi   +3 more
wiley   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab   +10 more
wiley   +1 more source