Results 41 to 50 of about 149,155 (277)

Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz, Neha V. Safi, Iliana Pliska‐Bloch, Ulrike W. Kaunzner, Ha Luu, Mert Sisman, Yi Wang, Thanh D. Nguyen, Sandra Hurtado Rúa, Susan A. Gauthier   +9 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

In Search of the Neurobiological Substrates for Social Playfulness in Mammalian Brains

, 2011
Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this ...
Panksepp, Jaak, Siviy, Stephen M.
core   +1 more source

Thermoreflectance Detection of Point Defects Resulting from Focused Ion Beam Milling

Advanced Engineering Materials, EarlyView.
Focused ion beam (FIB) milling is a common tool for nanoscale material processing, however irradiation damage, redeposition, and contamination can occur. We use several characterization tools to show FIB‐induced effects beyond 1 mm from the milled area.
Thomas W. Pfeifer, Eric R. Hoglund, Anton V. Ievlev, Patrick E. Hopkins   +3 more
wiley   +1 more source

The energetics of giant radio galaxy lobes from inverse Compton scattering observations

, 2011
Giant radio galaxy (GRG) lobes are excellent laboratories to study the evolution of the particle and B-field energetics. However, these results are based on assumptions of the shape and extension of the GRG lobe electron spectrum.
Abdo, Bondi, Carilli, Colafrancesco, Colafrancesco, Colafrancesco, Colafrancesco, Croston, Enßlin, Evans, Feigelson, Gopal-Krishna, Harris, Ishwara-Chandra, Isobe, Isobe, Isobe, Isobe, Isobe, Jamrozy, Kaneda, Mack, Massaro, P. Marchegiani, Rines, S. Colafrancesco, Sarazin, Tashiro, Tashiro, Yaji, Yamada   +30 more
core   +1 more source

A consistency check for Renormalons in Lattice Gauge Theory: beta^(-10) contributions to the SU(3) plaquette [PDF]

, 2000
We compute the perturbative expansion of the Lattice SU(3) plaquette to beta^(-10) order. The result is found to be consistent both with the expected renormalon behaviour and with finite size effects on top of that.Comment: 15 pages, 5 colour eps figures.
Di Renzo, F., Scorzato, L.
core   +4 more sources

Characterization of Defect Distribution in an Additively Manufactured AlSi10Mg as a Function of Processing Parameters and Correlations with Extreme Value Statistics

Advanced Engineering Materials, EarlyView.
Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt, Varma Kvvssn, Hossein Laieghi, Zia Uddin, Peyman Ansari, E. Kıvanç Sadak, Can Barış Toprak, Hüseyin Kızıl, Enrico Salvati   +8 more
wiley   +1 more source

Experimental Evaluation of 100Cr6 Steel Microindented Surfaces Under Lubricated Nonconformal Point Contacts

Advanced Engineering Materials, EarlyView.
The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi, Pasquale Guglielmi, Gianfranco Palumbo, Giuseppe Carbone   +3 more
wiley   +1 more source

A Hybrid Rule-Based Rough Set Approach to Explore Corporate Governance: From Ranking to Improvement Planning

Axioms
This research introduces a rule-based decision-making model to investigate corporate governance, which has garnered increasing attention within financial markets.
Kao-Yi Shen
doaj   +1 more source

Multicriteria Evaluation of Managerial Competences: An Application of the Dominance Principle and the Rough Set Theory

Foundations of Computing and Decision Sciences, 2014
This study demonstrates an analysis of executives based on their management competences. The aim of the study is to identify those executives that show a greater strategic alignment with the guidelines set by an organization.
Gaia Do Couto Ayrton Benedito, Autran Monteiro Gomes Luiz Flavio   +1 more
doaj   +1 more source