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BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

open access: yesFEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

open access: yesFEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima   +8 more
wiley   +1 more source
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On loops, dominators, and dominance frontier

Proceedings of the ACM SIGPLAN 2000 conference on Programming language design and implementation, 2000
This article explores the concept of loops and loop nesting forests of control-flow graphs, using the problem of constructing the dominator tree of a graph and the problem of computing the iterated dominance frontier of a set of vertices in a graph as guiding applications. The contributions of this article include: (1) An axiomatic characterization, as
openaire   +1 more source

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