Results 131 to 140 of about 9,423,140 (336)
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
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The domination number of K_{n}^3
Discussiones Mathematicae Graph Theory, 2014 Let K3n denote the Cartesian product Kn□Kn□Kn, where Kn is the complete graph on n vertices.
David W. Mauro +2 more
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Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
On domination number and distance in graphs
Discrete Applied Mathematics, 2016 A vertex set $S$ of a graph $G$ is a \emph{dominating set} if each vertex of $G$ either belongs to $S$ or is adjacent to a vertex in $S$. The \emph{domination number} $ (G)$ of $G$ is the minimum cardinality of $S$ as $S$ varies over all dominating sets of $G$.
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Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Total Domination Multisubdivision Number of a Graph
Discussiones Mathematicae Graph Theory, 2015 The domination multisubdivision number of a nonempty graph G was defined in [3] as the minimum positive integer k such that there exists an edge which must be subdivided k times to increase the domination number of G.
Avella-Alaminos Diana +3 more
doaj +1 more source
On the r-domination number of a graph
Discrete Mathematics, 1992 AbstractFor r > 0, let the r-domination number of a graph, dr, be the size of a smallest set of vertices such that every vertex of the graph is within distance r of a vertex in that set. This paper contains proofs that every graph with a spanning tree with at least n/2 leaves has dr ⩽ n/(2r); this compares with the easy upper bound of ⌈n/(2r + 1)⌉ for ...
Jerrold R. Griggs, Joan P. Hutchinson
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Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source