Results 111 to 120 of about 655,937 (417)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors [PDF]

, 2017
Background: Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed.
Ackerley, Karen, Addy, Joanne, Alexander, Claire, Allen, David, Allen, David, Anthony, Ben, Appleton, Mary Joy, Armitage, Jane, Armitage, Jane, Armitage, Jane, Aziz, Tahir, Barrass, Patricia, Bays, Eileen, Blair, Donna, Bland, Desmond, Bolton, Thomas, Botham, Lauren, Bowyer, Geoff, Brain, Richard, Brennan, James, Brooks, Carolyn, Bruce, David, Burton, Susan, Butterfield, Carol, Choudry, Fizzah, Clarke, Victoria, Clarkson, Steven, Danesh, John, Danesh, John, Danesh, John, Danesh, John, Danesh, John, Davies, Christine, Daynes, Michael, Dent, Alison, Di Angelantonio, Emanuele, Di Angelantonio, Emanuele, Di Angelantonio, Emanuele, Di Angelantonio, Emanuele, Di Angelantonio, Emanuele, Di Angelantonio, Emanuele, Dingwall, Hannah, Donovan, Jenny, Ellis, Karen, Fenton, James, Ford, Ian, Forsyth, Andrea, Franklin, Gayle, Furnival, Diane, Ghevaert, Cedric, Greaves, Michael, Green, Jane, Halson, Stuart, Halson, Stuart, Hammerton, Tracey, Henry, Rachel, Henry, Rachel, Henry, Rachel, Holmes, Kate, Howath, Cheryl, Humphries, Gareth, Hunt, Beverley J, Johnston, Kirstie, Johnston, Kirstie, Johnston, Kirstie, Kaptoge, Stephen, Kaptoge, Stephen, Kaptoge, Stephen, Kaptoge, Stephen, Kelly, Anne, King, Adam, King, Andrew, Le Huray, Bridget, Littler, Lara, Mant, Jonathan, Martin, Emma, McDermott, Alan, Mehenny, Susan, Mehenny, Susan, Mehenny, Susan, Miflin, Gail, Miflin, Gail, Mo, Alfred, Mochon, Cedric, Momodu, Abudu, Moore, Carmel, Moore, Carmel, Moore, Carmel, Moore, Carmel, Moore, Carmel, Moore, Carmel, Muhammed, Omer, Murphy, Gavin, Newland, Adrian C, Oates, Nicholas, Ouwehand, Willem H, Ouwehand, Willem H, Ouwehand, Willem H, Ouwehand, Willem H, Ouwehand, Willem H, Ouwehand, Willem H, Page, Lizanne, Parrondo, Will, Parvin-Cooper, Lee, Patel, Shilpa, Peakman, Tim, Potton, Maria, Poynton, Pat, Richardson, Penny, Roberts, David J, Roberts, David J, Roberts, David J, Roberts, David J, Roberts, David J, Roberts, David J, Ronaldson, Clive, Roost, Carolyn, Ryan, Christine, Sambrook, Jennifer, Sambrook, Jennifer, Senior, Peter, Sharpe, Sarah, Smith, Deborah, Sowerbutts, Gareth, Sowerby, Sandra, Spackman, Sarah, Spreckley, Kristian, Stanley, Sophie, Stennett, Louise, Stredder, Mike, Stubbins, Craig, Taylor, Samantha, Thake, Michael, Thompson, Simon G, Thompson, Simon G, Thompson, Simon G, Thompson, Simon G, Thompson, Simon G, Thomson, Claire, Thomson, Claire, Thomson, Claire, Tolkien, Zoe, Tolkien, Zoe, Towler, Jason, Turner, Marc, Turner, Ruth, Umrania, Yagnesh, Vincent, Helen, Wakeman, Alan, Wakeman, Paula, Walker, Matthew, Walker, Matthew, Walker, Matthew, Walker, Matthew, Walker, Matthew, Walker, Matthew, Walsh, Gemma, Warren, Kimberley, Watkins, Nicholas A, Weatherill, Candy, Wheatley, Keith, Williams, Caroline, Williams, Joanna, Williams, Lindsay, Williamson, Lorna, Wong, Henna, Woods, Lynn, Wright, Tracey   +167 more
core   +1 more source

Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation

FEBS Letters, Volume 599, Issue 6, Page 838-847, March 2025.
Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese, Laura A. Hansen, Sándor Lovas   +2 more
wiley   +1 more source

Conservation fundraising: Evidence from social media and traditional mail field experiments

Conservation Letters, 2023
Funding shortages limit conservation impact, making it vital to find effective fundraising methods. To explore how traditional and digital conservation fundraising methods perform, we conducted real‐world field experiments by using direct‐mail and ...
Takahiro Kubo, Hide‐Fumi Yokoo, Diogo Veríssimo   +2 more
doaj   +1 more source

Calcium‐sensing receptor‐ and ADAM10‐mediated klotho shedding is regulated by tetraspanin 5

FEBS Letters, Volume 599, Issue 6, Page 866-875, March 2025.
The G protein‐coupled calcium‐sensing receptor (CaSR) and the disintegrin/metalloprotease ADAM10 in the renal distal convoluted tubule control systemic levels of Klotho, a cell and tissue homeostasis‐preserving factor. We show that CaSR‐induced cleavage of membrane‐bound αKlotho by ADAM10 requires tetraspanin 5 (Tspan5), a scaffolding and chaperone ...
Zhenan Liu, Joonho Yoon, Eunyoung Lee, Audrey N. Chang, R. Tyler Miller   +4 more
wiley   +1 more source

Consideraţii cu privire la originea şi aria de răspândire a unor proprietăţi laice din ţinutul Iaşi (III) [PDF]

Revista de Etnologie şi Culturologie, 2019
This study is developed based on documents included in prestigious collections of documents: Documenta Romaniae Historica. A. Moldova; Documents on the history of Romania. A.
Alexandru FURTUNĂ
doaj  

User Donations in a Crowdsourced Video System [PDF]

arXiv, 2019
Crowdsourced video systems like YouTube and Twitch.tv have been a major internet phenomenon and are nowadays entertaining over a billion users. In addition to video sharing and viewing, over the years they have developed new features to boost the community engagement and some managed to attract users to donate, to the community as well as to other ...
arxiv  

Sister-to-sister oocyte donation: couples’ experiences with regard to genetic ties [PDF]

, 2016
Objective: This study aimed to gain an in-depth understanding of the experiences of genetic ties in intrafamily oocyte donation families. Background: Previous research has shown that most mothers have a good and stable relationship with their donor ...
Buysse, Ann, De Sutter, Petra, Pennings, Guido, Provoost, Veerle, Van Parys, Hanna, Wyverkens, Elia   +5 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Collection of horseshoes in the holdings of Museum Complex named after I.Ya. Slovtsov

Вестник археологии, антропологии и этнографии, 2019
One of the earliest crafts practised in Russian urban centres was blacksmithing, necessary for the manufacture of tools for all types of material production. One of the most intrinsic functions of a blacksmith consisted in forging horseshoes.
Semyonova V.I.
doaj   +1 more source